Re: Breast Cancer and Carbohydrates

[Guest guest]

This is from Dr. Roy Jamron, in the celiac group. Thought those of you

who are low carb diets would like this!!!

-- Heidi Jean

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>The featured story in current health news has been about the link between a

>high-carb diet and breast cancer. Recently I posted on the List the recent

>study " Malignancy and mortality in people with coeliac disease: population

>based cohort study " which found that breast cancer risk was significantly

>lower in celiacs on a GF-diet. Off-hand, I would say there is a very high

>probability of a connection between these two results. A GF-diet is likely

>to include less refined carbohydrates in addition to the elimination of

>gluten.

>

>----------

>Study: Shunning carbs may cut breast-cancer risk

>http://www.azstarnet.com/sn/health/33088.php

>

>CBS News story with video (Paste address together)

>http://www.cbsnews.com/stories/2004/08/06/earlyshow/contributors/emilysenay/

>main634382.shtml

>

>----------

>Cancer Epidemiology Biomarkers & Prevention Vol. 13, 1283-1289, August 2004

>

>Carbohydrates and the Risk of Breast Cancer among Mexican Women

>

>Isabelle Romieu, Lazcano-Ponce, a -Zamorano,

>Walter Willett and Mauricio -Avila

>

>Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico and

>Departments of Nutrition and Epidemiology, Harvard School of Public Health

>and Channing Laboratory, Department of Medicine, Brigham and Women's

>Hospital and Harvard Medical School, Boston, Massachusetts

>

>Full-text HTML (free):

>http://cebp.aacrjournals.org/cgi/content/full/13/8/1283

>

>Full-text PDF (free):

>http://cebp.aacrjournals.org/cgi/reprint/13/8/1283

>

>Abstract

>

>Objective: High carbohydrate intake has been hypothesized to be a risk

>factor for breast cancer, possibly mediated by elevated levels of free

>insulin, estrogens, and insulin-like growth factor-1. Therefore, we

>conducted a population-based case-control study among a Mexican population

>characterized by relatively low fat and high carbohydrate intakes. Methods:

>Women ages 20 to 75 years, identified through six hospitals in Mexico City

>(n = 475), were interviewed to obtain data relating to diet (using a food

>frequency questionnaire) and breast cancer risk factors. Controls (n =

>1,391) were selected from the Mexico City population using a national

>sampling frame. Results: Carbohydrate intake was positively associated with

>breast cancer risk. Compared with women in the lowest quartile of total

>carbohydrate intake, the relative risk of breast cancer for women in the

>highest quartile was 2.22 [95% confidence interval (95% CI) 1.63-3.04],

>adjusting for total energy and potential confounding variables (P for trend

>< 0.0001). This association was present in premenopausal and postmenopausal

>women (for highest versus lowest quartile, odds ratio 2.31, 95% CI 1.36-

>3.91 in premenopausal women and odds ratio 2.22, 95% CI 1.49-3.30 in

>postmenopausal women). Among carbohydrate components, the strongest

>associations were observed for sucrose and fructose. No association was

>observed with total fat intake. Discussion: In this population, a high

>percentage of calories from carbohydrate, but not from fat, was associated

>with increased breast cancer risk. This relation deserves to be

>investigated further, particularly in populations highly susceptible to

>insulin resistance.

>

>----------

>BMJ. 2004 Jul 21 [Epub ahead of print]

>

>Full-text PDF (free):

>http://bmj.bmjjournals.com/cgi/reprint/bmj.38169.486701.7Cv1

>

>Malignancy and mortality in people with coeliac disease: population based

>cohort study.

>

>West J, Logan RF, CJ, Hubbard RB, Card TR.

>

>Division of Epidemiology and Public Health, University of Nottingham,

>Queen's Medical Centre, Nottingham NG7 2UH.

>

>OBJECTIVE: To quantify the risks of malignancy and mortality in people with

>coeliac disease compared with the general population. DESIGN: Population

>based cohort study. SETTING: General practice research database.

>PARTICIPANTS: 4732 people with coeliac disease and 23 620 matched controls.

>MAIN OUTCOME MEASURES: Hazard ratios for malignancy and mortality. RESULTS:

>Of the 4732 people with coeliac disease, 134 (2.8%) had at least one

>malignancy and 237 (5.0%) died. The overall hazard ratios were: for any

>malignancy 1.29 (95% confidence interval 1.06 to 1.55), for mortality 1.31

>(1.13 to 1.51), for gastrointestinal cancer 1.85 (1.22 to 2.81), for breast

>cancer 0.35 (0.17 to 0.72), for lung cancer 0.34 (0.13 to 0.95), and for

>lymphoproliferative disease 4.80 (2.71 to 8.50). The increased risk was

>primarily in the first year after diagnosis, with the risk for only

>lymphoproliferative disease remaining significantly raised thereafter.

>After excluding events in the year after diagnosis, the hazard ratio for

>malignancy was 1.10 (0.87 to 1.39) and for mortality was 1.17 (0.98 to

>1.38), giving absolute excess rates of 6 and 17 per 10 000 person years,

>respectively. CONCLUSIONS: People with coeliac disease have modest

>increases in overall risks of malignancy and mortality. Most of this excess

>risk occurs in the year of follow up after diagnosis. People with coeliac

>disease also have a noticeably reduced risk of breast cancer. The mechanism

>of this merits further attention as it may provide insights into the cause

>of this common malignancy.

>

>PMID: 15269095 [PubMed - as supplied by publisher]

>

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>

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