Guest guest Posted April 17, 2008 Report Share Posted April 17, 2008 Well, it is if your a female lab mouse. http://www.ncbi.nlm.nih.gov/pubmed/17416441 Creatine improves health and survival of mice. Department of Neurology, University of Munich, Klinikum Grosshadern, Marchioninistr. 15, Munich D-81377, Germany. The supplementation of creatine (Cr) has a marked neuroprotective effect in mouse models of neurodegenerative diseases. This has been assigned to the known bioenergetic, anti-apoptotic, anti-excitotoxic, and anti-oxidant properties of Cr. As aging and neurodegeneration share pathophysiological pathways, we investigated the effect of oral Cr supplementation on aging in 162 aged C57Bl/6J mice. Outcome variables included " healthy " life span, neurobehavioral phenotyping, as well as morphology, biochemistry, and expression profiling from brain. The median healthy life span of Cr-fed mice was 9% higher than in control mice, and they performed significantly better in neurobehavioral tests. In brains of Cr-treated mice, there was a trend towards a reduction of reactive oxygen species and significantly lower accumulation of the " aging pigment " lipofuscin. Expression profiling showed an upregulation of genes implicated in neuronal growth, neuroprotection, and learning. These data show that Cr improves health and longevity in mice. Cr may be a promising food supplement to promote healthy human aging. Regards, Johan Bastiaansen Hasselt, Belgium Quote Link to comment Share on other sites More sharing options...
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