Naltrexone-induced augmentation of sexual response in men.

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Naltrexone-induced augmentation of sexual response in men.

Sathe RS, Komisaruk BR, Ladas AK, Godbole SV.

Maritosexual and Reproductive Research Institute (MARRI), Pune,

Maharashtra, India. sexdoc9@...

BACKGROUND: To ascertain the role of endogenous opioids in sexual

response, naltrexone, an opiate receptor antagonist, was administered

to men, and its effect on selected self-report measures of sexual

response to masturbation was recorded. METHODS: The data are based on

results from 20 healthy, sexually active (alone or with a partner)

men, aged 20-29 years, who ingested naltrexone (25 mg/day x 3) or

placebo in a randomized, double-blind crossover design. There was at

least a 14-day interval between drug and placebo treatment. Between

18 and 22 h after the most recent dose of drug or placebo, subjects

viewed sexually explicit videos in privacy for 2 h. They were

instructed to masturbate and have as many orgasms as desired. The

following three different self-report measures of their responses

were recorded: number of orgasms; intensity of sexual arousal, and

orgasmic intensity. RESULTS: Under the naltrexone condition, the

volunteers experienced a significantly greater mean number of orgasms

(3.4 +/- 0.2 SEM) than under the placebo condition (2.6 +/- 0.3). The

total number of orgasms was 67 under the naltrexone condition and 51

under the placebo condition. At the first orgasm, the measure of

intensity of arousal was significantly greater in the naltrexone (3.9

+/- 0.2) than placebo (3.4 +/- 0.2) condition, and the measure of

orgasmic intensity was significantly greater in the naltrexone (3.7

+/- 0.2) than in the placebo (3.0 +/- 0.3) condition. CONCLUSIONS:

The present study provides evidence that endogenous opioids modulate

orgasmic response and the perceived intensity of sexual arousal and

orgasm in men. The findings suggest that naltrexone could be

clinically useful in cases of inhibited sexual desire and erectile

dysfunction.

Publication Types:

Clinical Trial

Randomized Controlled Trial

PMID: 11395188 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

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