Guest guest Posted February 10, 2006 Report Share Posted February 10, 2006 > > > > > Hi Mike, below is an out take on naloxone being used as a possible > > treatment for brain diseases, ALS being one. I see the paper as an > > independant report on how LDN could be real. Until there is > clinical > > data on how LDN effects people with a serious disease, we are doing > > our own experiments. Hope Dr. Jill and Dr. Myra Gironi can > > provide positve reports. The report below sort of confirms naloxone > > (naltrexone) could help, at least in rats. My guess is that one > should > > be on LDN for about a year before you can get a sense if you're > > holding your own (unless you're getting worse and then what do you > > do?). Where did you get your LDN and how much were you taking? Did > > your symptoms change after you stopped LDN? > > > > > > OPIOIDS, BRAIN INFLAMMATION, AND... > > REFERENCES > > > > Increasing evidence has suggested that inflammation in the brain is > > closely associated with the pathogenesis of several degenerative > > neurologic disorders, including Parkinson's disease, Alzheimer's > > diseases, multiple sclerosis, amyotrophic lateral sclerosis, and > AIDS > > dementia. The hallmark of brain inflammation is the activation of > > glial cells, especially that of microglia that produce a variety of > > proinflammatory and neurotoxic factors, including cytokines, fatty > > acid metabolites, free radicals—such as nitric oxide (NO) and > > superoxide. Excessive production of NO, as a consequence of nitric > > oxide synthase induction in activated glia, has been attributed to > > participate in neurodegeneration. Using primary mixed neuron-glia > > cultures and glia-enriched cultures prepared from embryonic rodent > > brain tissues, we have systemically studied the relationship > between > > the production of NO and neurodegeneration in response to > stimulation > > by the inflammagen lipopolysaccharide. This review summarizes our > > recent findings on the kinetics of NO generation, the relative > > contribution of microglia and astrocytes to NO accumulation, the > > relationship between NO production and neurodegeneration, and > points > > of intervention along the pathways associated with NO generation to > > achieve neuroprotection. We also describe our results relating to > the > > effect of several opioid-related agents on microglial activation > and > > neuroprotection. Among these agents, the opioid receptor antagonist > > naloxone, especially its non-opioid enantiomer (+)-naloxone, > promises > > to be of potential therapeutic value for the treatment of > > inflammation-related diseases. > > http://www.annalsnyas.org/cgi/content/full/962/1/318 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 2006 Report Share Posted February 20, 2006 Hi , I had gotten the LDN frpm Skip's and immediatly began taking 4.5, then went down to 3.0 as I was getting very spastic (legs muscles were very shaky) when arising from bed in the morning. I got my LDN from Skip's again on 2/15/06 and spoke with Skip after hearing what everyone here was recommending. He said that I was taking to much to fast and didn't take it for long enough. He said I should take 1.5 for 30 days, then 3.0 for 30, then 4.5. That is what I am doing this time. Thanks for the info on the brain inflamation. Mike > > > Hi Mike, below is an out take on naloxone being used as a possible > treatment for brain diseases, ALS being one. I see the paper as an > independant report on how LDN could be real. Until there is clinical > data on how LDN effects people with a serious disease, we are doing > our own experiments. Hope Dr. Jill and Dr. Myra Gironi can > provide positve reports. The report below sort of confirms naloxone > (naltrexone) could help, at least in rats. My guess is that one should > be on LDN for about a year before you can get a sense if you're > holding your own (unless you're getting worse and then what do you > do?). Where did you get your LDN and how much were you taking? Did > your symptoms change after you stopped LDN? > > > OPIOIDS, BRAIN INFLAMMATION, AND... > REFERENCES > > Increasing evidence has suggested that inflammation in the brain is > closely associated with the pathogenesis of several degenerative > neurologic disorders, including Parkinson's disease, Alzheimer's > diseases, multiple sclerosis, amyotrophic lateral sclerosis, and AIDS > dementia. The hallmark of brain inflammation is the activation of > glial cells, especially that of microglia that produce a variety of > proinflammatory and neurotoxic factors, including cytokines, fatty > acid metabolites, free radicals—such as nitric oxide (NO) and > superoxide. Excessive production of NO, as a consequence of nitric > oxide synthase induction in activated glia, has been attributed to > participate in neurodegeneration. Using primary mixed neuron-glia > cultures and glia-enriched cultures prepared from embryonic rodent > brain tissues, we have systemically studied the relationship between > the production of NO and neurodegeneration in response to stimulation > by the inflammagen lipopolysaccharide. This review summarizes our > recent findings on the kinetics of NO generation, the relative > contribution of microglia and astrocytes to NO accumulation, the > relationship between NO production and neurodegeneration, and points > of intervention along the pathways associated with NO generation to > achieve neuroprotection. We also describe our results relating to the > effect of several opioid-related agents on microglial activation and > neuroprotection. Among these agents, the opioid receptor antagonist > naloxone, especially its non-opioid enantiomer (+)-naloxone, promises > to be of potential therapeutic value for the treatment of > inflammation-related diseases. > http://www.annalsnyas.org/cgi/content/full/962/1/318 > > > I posted a last week in regards to PLS and LDN. There have been no > > responses. Does that mean nobody is familiar with PLS and LDN? > > > > PLS is in the same " family " as ALS, are there any persons who have > > used LDN who have ALS and have had any success? > > > > I had taken LDN for 1 1/2 months last year, but I had such a worsening > > of symptoms I stopped. I was afraid that if I kept taking LDN things > > would just continue to worsen, but I'd like to investigate it more vs. > > just giving up entirely. > > > > Thanks, > > > > Mike > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 2006 Report Share Posted February 20, 2006 Hi , I had gotten the LDN frpm Skip's and immediatly began taking 4.5, then went down to 3.0 as I was getting very spastic (legs muscles were very shaky) when arising from bed in the morning. I got my LDN from Skip's again on 2/15/06 and spoke with Skip after hearing what everyone here was recommending. He said that I was taking to much to fast and didn't take it for long enough. He said I should take 1.5 for 30 days, then 3.0 for 30, then 4.5. That is what I am doing this time. Thanks for the info on the brain inflamation. Mike > > > Hi Mike, below is an out take on naloxone being used as a possible > treatment for brain diseases, ALS being one. I see the paper as an > independant report on how LDN could be real. Until there is clinical > data on how LDN effects people with a serious disease, we are doing > our own experiments. Hope Dr. Jill and Dr. Myra Gironi can > provide positve reports. The report below sort of confirms naloxone > (naltrexone) could help, at least in rats. My guess is that one should > be on LDN for about a year before you can get a sense if you're > holding your own (unless you're getting worse and then what do you > do?). Where did you get your LDN and how much were you taking? Did > your symptoms change after you stopped LDN? > > > OPIOIDS, BRAIN INFLAMMATION, AND... > REFERENCES > > Increasing evidence has suggested that inflammation in the brain is > closely associated with the pathogenesis of several degenerative > neurologic disorders, including Parkinson's disease, Alzheimer's > diseases, multiple sclerosis, amyotrophic lateral sclerosis, and AIDS > dementia. The hallmark of brain inflammation is the activation of > glial cells, especially that of microglia that produce a variety of > proinflammatory and neurotoxic factors, including cytokines, fatty > acid metabolites, free radicals—such as nitric oxide (NO) and > superoxide. Excessive production of NO, as a consequence of nitric > oxide synthase induction in activated glia, has been attributed to > participate in neurodegeneration. Using primary mixed neuron-glia > cultures and glia-enriched cultures prepared from embryonic rodent > brain tissues, we have systemically studied the relationship between > the production of NO and neurodegeneration in response to stimulation > by the inflammagen lipopolysaccharide. This review summarizes our > recent findings on the kinetics of NO generation, the relative > contribution of microglia and astrocytes to NO accumulation, the > relationship between NO production and neurodegeneration, and points > of intervention along the pathways associated with NO generation to > achieve neuroprotection. We also describe our results relating to the > effect of several opioid-related agents on microglial activation and > neuroprotection. Among these agents, the opioid receptor antagonist > naloxone, especially its non-opioid enantiomer (+)-naloxone, promises > to be of potential therapeutic value for the treatment of > inflammation-related diseases. > http://www.annalsnyas.org/cgi/content/full/962/1/318 > > > I posted a last week in regards to PLS and LDN. There have been no > > responses. Does that mean nobody is familiar with PLS and LDN? > > > > PLS is in the same " family " as ALS, are there any persons who have > > used LDN who have ALS and have had any success? > > > > I had taken LDN for 1 1/2 months last year, but I had such a worsening > > of symptoms I stopped. I was afraid that if I kept taking LDN things > > would just continue to worsen, but I'd like to investigate it more vs. > > just giving up entirely. > > > > Thanks, > > > > Mike > > > Quote Link to comment Share on other sites More sharing options...
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