Re: 's notes on German Study?

[Guest guest]

The following is a small section of 's notes from the conference last year.

Dr Mir from Germany ran a double blind randomized trial. 60 patients, 30 on LDN, 30 on placebo, 3mg LDN TAKEN AT 9AM (no typo) .. for 10 days .. Patients were PPMS or SPMS .. Did a pre and post neurological exam and question sheet .. Now this is interesting .. the test showed that LDN did not significantly help STATISTICALLY .. however .. when you look at it closer .. one third of the patients were 'responders' ie. they responded within about 7 days ... a doctor from Ireland backed him up there .. Dr P Crowley said that the LDN website is misleading because it implies everyone will respond but in his practice only about one third of people seem to respond .. Dr Gluck clarified .. It is a bonus if you are a responder ie get improvement .. the numbers on the website include those that don't progress .. that is the cream .. the improvements are the sprinkles .. Also interesting .. although .. the trial concluded no statistical change when Dr Mir asked Docs .. 82% of docs could SEE the improvements and 72% of patients could feel them .. so there was a change .. just ones that the parameters of the trial did not pick up .. Dr Gluck pointed out it was remarkable the effects and results of the 10 day trial because LDN was taken at 9AM .. he asked that next time Dr Mir give LDN at night .. it was given in the AM to avoid sleepless nights and 3mg to avoid .. spasticity .. Dr Mir showed that although LDN works it can still fail a clinical trial .. that was an eye opener .. there are no many different parameters .. that is why it convinced me me need a large scale double blind placebo for like 300 people for 12 months that no one can dispute .. but you know .. It could even fail that depending on the parameters .. It was just fascinating .. the test in Germany ended April 2005 I think.

[low dose naltrexone] Bren ? German Study?

What study was done in Germany?

Thank you for your info.

DestinyBren <b63powell@...> wrote:

You may get symptom improvement taking LDN at other times other than between 9pm and 3am but you will not get a halt in your disease progression. If you want your disease progression halted then LDN MUST be taken between the hours of 9pm and 3am. The German study proved that LDN does not work when LDN is given in another time frame other than 9pm and 3am. Approx. 30% may get symptom improvement if LDN is given before 9pm or after 3am and disease progression will not be halted.

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