What diseases has LDN been useful for and how effective is it?

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This is from the LDN Website - www.low dose naltrexone.org

What diseases has it been useful for and how effective is it?

> Bernard Bihari, MD has described beneficial effects of LDN on a

variety of diseases:

Cancers and Other Diseases LDN Helps

Breast Cancer

Carcinoid

Colon & Rectal Cancer

Glioblastoma

Liver Cancer

Lung Cancer (Non-Small Cell)

Lymphocytic Leukemia

Lymphoma (Hodgkin's and

Non-Hodgkin's)

Malignant Melanoma

Multiple Myeloma

Neuroblastoma

Ovarian Cancer

Pancreatic Cancer

Prostate Cancer (untreated)

Renal Cell Carcinoma

Throat Cancer

Uterine Cancer

ALS (Lou Gehrig's Disease)

Alzheimer's Disease

Behcet's Disease

Celiac Disease

Chronic Fatigue Syndrome

Crohn's Disease

Emphysema (COPD)

Fibromyalgia

HIV/AIDS

Irritable Bowel Syndrome (IBS)

Multiple Sclerosis (MS)

Parkinson's Disease

Pemphigoid

Primary Lateral Sclerosis (PLS)

Psoriasis

Rheumatoid Arthritis

Sarcoidosis

Systemic Lupus (SLE)

Ulcerative Colitis

Wegener's Granulomatosis

> LDN has demonstrated efficacy in hundreds of cases.

Cancer. As of mid-2004, Dr. Bihari reports having treated over 300

patients with cancer that had failed to respond to standard

treatments. Of that group, some 50%, after four to six months

treatment with LDN, began to demonstrate a halt in cancer growth and,

of those, over one-third have shown objective signs of tumor

shrinkage.

Autoimmune disease. Within the group of patients who presented with

an autoimmune disease (see above list), none have failed to respond

to LDN; all have experienced a halt in progression of their illness.

In many patients there was a marked remission in signs and symptoms

of the disease. The greatest number of patients within the autoimmune

group are people with multiple sclerosis, of whom there are now some

400 in Dr. Bihari's practice. Less than 1% of these patients has ever

experienced a fresh attack of MS while they maintained their regular

LDN nightly therapy.

HIV/AIDS. As of September 2003, Dr. Bihari has been treating 350 AIDS

patients using LDN in conjunction with accepted AIDS therapies. Over

the past 7 years over 85% of these patients showed no detectable

levels of the HIV virus — a much higher success rate than most

current AIDS treatments, and with no significant side effects. It is

also worth noting that many HIV/AIDS patients under Dr. Bihari's care

have been living symptom-free for years taking only LDN with no other

medications.

> How is it possible that one medication can impact such a wide range

of disorders?

The disorders listed above all share a particular feature: in all of

them, the immune system plays a central role — and low blood levels

of endorphins are generally present, playing a role in the disease-

associated immune deficiencies.

Research by others — on neuropeptide receptors expressed by various

human tumors — has found opioid receptors in many types of cancer:

Brain tumors (both astrocytoma and glioblastoma)

Breast cancer

Endometrial cancer

Head and neck squamous cell carcinoma

Myeloid leukemia

Lung cancer (both small cell and non-small cell)

Neuroblastoma and others...

These findings suggest the possibility for a beneficial LDN effect in

a wide variety of common cancers.