Guest guest Posted February 27, 2006 Report Share Posted February 27, 2006 http://www.thyroid-info.com/articles/hemachromatosis-iron.htmhttp://www.ithyroid.com/anemia.htmhttp://www.goodhormonehealth.com/Iron%20Deficiency%20and%20FatigueNov04.pdfThe following is probably the best explanation of what happens:http://www.ajcn.org/cgi/content/full/75/4/743Iron deficiency impairs thyroid metabolism in animal and human studies (6–9). In rats, iron deficiency anemia lowers plasma thyroid hormone concentrations, reduces the activity of hepatic thyroxine deiodinase, impairs the peripheral conversion of thyroxine to triiodothyronine, and blunts the thyrotropin response to thyrotropin-releasing hormone (6, 7). Iron-deficient adults have lower circulating concentrations of thyroxine and triiodothyronine (8, 9) and higher concentrations of thyrotropin (8) than do healthy control subjects. Iron deficiency may influence IDD through alterations in the central nervous system control of thyroid metabolism (6) or through modifications in nuclear triiodothyronine binding (7). Also, the initial steps of thyroid hormone synthesis—iodide incorporation into tyrosine residues of thyroglobulin and covalent bridging of the residues—are catalyzed by heme-containing thyroperoxidases. Other iron-containing enzymes [eg, cytochrome oxidase, myeloperoxidase, and succinate dehydrogenase (ubiquinone)] are sensitive to iron deficiency (23). Theoretically, severe iron deficiency could lower thyroperoxidase activity and interfere with thyroid hormone synthesis. Quote Link to comment Share on other sites More sharing options...
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