Action of excess Si on mineral metabolism

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Biol Trace Elem Res. 1993 May-Jun;37(2-3):107-14. Related Articles, Links The action of excessive, inorganic silicon (Si) on the mineral metabolism of calcium (Ca) and magnesium (Mg).Najda J, Gminski J, Drozdz M, Danch A.Department of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.The influence of silicon

treatment on the levels of calcium and magnesium in blood serum and tissues was studied in rats. The concentrations of both elements were estimated in samples of sera and tissues of rats receiving per os a soluble, inorganic silicon compound--sodium metasilicate nonahydrate (Na2SiO3.9H2O (REACHIM, USSR)), dissolved in the animals' drinking water. A decrease of magnesium concentration in serum was observed with accompanying elevation of registered calcemia. Moreover, a reduction of tissue calcium levels was found with a simultaneous increase of magnesium tissue pool. The results provide evidence for silicon involvement in mineral metabolism. It could result in a modification of pathological processes concerning bone tissue.

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