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http://www.bruha.com/pfpc/html/silica.html Silica© 1996 - 2004 PFPC Anasuya A, Bapurao S, Paranjape PK - "Fluoride and silicon intake in normal and endemic fluorotic areas" J Trace Elem Med Biol 10(3):149-55 (1996)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=

8905558 & form=6 & db=m & Dopt=r Brandt-Rauf PW, S, Hemminki K, Koskinen H, Vainio H, Niman H, Ford J - "Serum oncoproteins and growth factors in asbestosis and silicosis patients" Int J Cancer 50(6):881-5 (1992)(G proteins) Busey RH, Schwartz E, Mesmer RE - "Fluorosilicate Equilibria in NaCl Solutions from 0 to 60%C" Inorg. Chem. 19, 758 (1980) Chaigneau M, Chastagnier M - "Determination of silicon dioxide in colloidal silica" Ann Pharm Fr 150(5-6):314-6 (1992)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 1307677 & form=6 & db=m & Dopt=r Chen TA, Marshall WL - " Amorphous Silica Solubilities - VI. Behavior in Pure Water and Aqueous Sodium Chloride, Sodium Sulfate, Magnesium Chloride and Magnesium Sulfate Solutions to 350%C" Geochim. Cosmochim. Acta. 46, 279 (1982) LN, Mao Y, AO, Saffiotti U - "Direct interaction between crystalline silica and DNA - a proposed model for silica carcinogenesis" Scand J Work Environ Health 21 Suppl 2:22-6 (1995)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=

8929683 & form=6 & db=m & Dopt=r Darcy A, Galijatovic A, Barth R, Kenny T, Krantzman KD, Schoolcraft TA - "Molecular dynamics simulations of silicon-fluorine etching" J Mol Graph 14(5):260-71, 278 (1996)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 9097232 & form=6 & db=m & Dopt=r Dong YT - "The clinical features of 160 cases of acute sodium silicon fluoride poisoning" Chung Hua Yu Fang I Hsueh Tsa Chih 25(5):269-71 (1991)http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?ui d=1773667 & form=6 & db=m & Dopt=r Dong M, Nio Y, Tamura K, Song MM, Guo KJ, Guo RX, Dong YT - "Ki-ras point mutation and p53 expression in human pancreatic cancer: a comparative study among Chinese, Japanese, and Western patients" Cancer Epidemiol Biomarkers Prev9(3):279-84 (2000)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 10750666 & form=6 & db=m & Dopt=r(SEE: WILLIAMS, 1993 & 1995) Eisinger J, t D - "Effects of silicon, fluoride, etidronate and magnesium on bone mineral density: a retrospective study" Magnes Res 6(3):247-9 (1993)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 8292498 & form=6 & db=m & Dopt=r Elferink JG, Ebbenhout JL - "Asbestos-induced activation of the respiratory burst in rabbit neutrophils" Res Commun Chem Pathol Pharmacol 61(2):201-11 (1988)(G proteins) Fabbri L, Mapp C, Rossi A, Cortese S, Saia B - "Chronic broncopneumopathy and pneumoconiosis in workers employed in phosphoric acid production" Lav Um 29(2):50-7(1977)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 865215 & form=6 & db=m & Dopt=r Fillmore CM, Petralia SA, Dosemeci M - "Cancer mortality in women with probable exposure to silica: a death certificate study in 24 states of the U.S. " Am J Ind Med 36(1):122-8 (1999)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 10361596 & form=6 & db=m & Dopt=r(more thyroid cancer) Forbes WF, Agwani N - "A suggested mechanism for aluminum biotoxicity" J Theor Biol 171(2):207-14(1994)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 7844998 & form=6 & db=m & Dopt=r Hadfield MG, Adera T, B, Fortner-Burton CA, Gibb RD, Mumaw V - "Human brain tumors and exposure to metal and

non-metal elements: a case-control study" J Environ Pathol Toxicol Oncol 17(1):1-9 (1998)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 9490316 & form=6 & db=m & Dopt=r Hattori T, Maehashi H - "Enhancement of the twitch of bull frog sartorius muscle by fluorides" Jpn J Pharmacol 40(1):191-3 (1986)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 3485732 & form=6 & db=m & Dopt=r Hershey CO, Hershey LA, Varnes A, Vibhakar SD, Lavin P, Strain WH - "Cerebrospinal fluid trace element content in dementia: clinical, radiologic, and pathologic correlations" Neurology 33(10):1350-3 (1983)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 6684234 & form=6 & db=m & Dopt=r Jacqmin-Gadda H, Commenges D, Letenneur L, Dartigues JF - "Silica and aluminum in drinking water and cognitive impairment in the elderly" Epidemiology 7(3):281-5 (1996)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 8728442 & form=6 & db=m & Dopt=r Kromer G, Schauenstein K, Dietrich H, Fassler R, Wick G - "Mechanisms of T cell hyperreactivity in obese strain (OS) chickens with spontaneous autoimmune thyroiditis: lack in nonspecific suppression is due to a primary adherent cell defect' J Immunol 138(7):2104-9 (1987)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 2951433 & form=6 & db=m & Dopt=r Lablanquie P, Souza ACA, de Souza GGB, Morin P, Nenner I - "Relaxation processes following excitation and ionization of SiF4 in the vicinity of the silicon 2p threshold. II. Dissociation of the molecular ions". Journal of Chemical Physics, 90, 7078 (1989) Laster MJ, Eger EI 2nd, Cherry WR, Gong D - "Fractional Distillation of Acid Contaminants from Sevoflurane" Anesth Analg 91 (4):985-988 (2000)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 7688524 & form=6 & db=m & Dopt=r Levy JS, Koritzer RT - "Enamel silicon and fluoride relationships demonstrating a surface silicon effect that facilitates fluoride uptake" J Dent Res 55(5):733-7 (1976)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 1067290 & form=6 & db=m & Dopt=r Mancino D, Bevilacqua N - "Adjuvant Effect of Amorphous Silica on the Immune Response to Various Antigens in Guinea Pigs" Inter Arch Allergy Appl Immunol 53: 97-103 (1977) Marshall WL, Chen CT - "Amorphous Silica Solubilities - VI. Postulated Sulfate-Silicic Acid

Solution Complex" Geochim. Cosmochim. Acta. 46:367 (1982) Marshall WL - "Amorphous Silica Solubilities - I. Behavior in Aqueous Sodium Nitrate Solutions: 23-300%C, 0.6 Molal" Geochim. Cosmochim. Acta. 44:907 (1980) Marshall WL, Warakomski JM - "Amorphous Silica Solubilities - II. Effect of Aqueous Salt Solutions at 25%C" Geochim. Cosmochim. Acta. 44: 915 (1980) Marshall WL - "Amorphous Silica Solubilities - III. Activity Coefficient Relations and Predictions of Solubility Behavior in Salt Solutions, 0-350%C" Geochim. Cosmochim. Acta. 44: 925 (1980) McConnell EE, Rutter HA, Ulland BM, JA - "Chronic effects of dietary exposure

to amosite asbestos and tremolite in F344 rats" Environ Health Perspect 53:27-44 (1983)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 6319118 & form=6 & db=m & Dopt=r Najda J, Gminski J, Drozdz M, Danch A - "The action of excessive, inorganic silicon (Si) on the mineral metabolism of calcium (Ca) and magnesium (Mg)." Biol Trace Elem Res 37(2-3):107-14(1993)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=

7688524 & form=6 & db=m & Dopt=r Najda J, Goss M, Gminski J, Weglarz L, Siemianowicz K, Olszowy Z - "The antioxidant enzymes activity in the conditions of systemic hypersilicemia" Biol Trace Elem Res 42(1):63-70 (1994)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 7986662 & form=6 & db=m & Dopt=r Najda J, Gminski J, Drozdz M, Danch A - "Silicon metabolism. The interrelations of inorganic silicon (Si) with systemic iron (Fe), Zinc (Zn), and copper (Cu) pools in the rat" Biol Trace

Elem Res 34(2):185-95 (1992)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 1381938 & form=6 & db=m & Dopt=r Najda J, Gminski J - "Silica in pathophysiology of the central nervous system" Pol Tyg Lek 47(20-21):459-60 (1992) Najda J, Gminski J, Drozdz M, Zych F - "The influence of inorganic silicon (Si) on pituitary-thyroid axis" Biol Trace Elem Res 37(2-3):101-6 (1993)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 7688523 & form=6 & db=m & Dopt=r(subclinical hypothyroidism) Najda J, Gminski J, Drozdz M, Flak A - "The effect of silicon (Si) on lipid parameters in blood serum and arterial wall" Biol Trace Elem Res 31(3):235-47 (1991)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 1723614 & form=6 & db=m & Dopt=r Najda J, Gminski J - "Silicon--metabolic aspects of its effect on human body" Przegl Lek

47(11):756-9 (1990) Polissar L, Severson RK, Boatman ES, DB - "Cancer incidence in relation to asbestos in drinking water in the Puget Sound region" Am J Epidemiol 116(2):314-28 (1982)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 7114040 & form=6 & db=m & Dopt=r(Cancer of the thyroid, testis, etc.)Rajnicek A, McCaig C - "Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways" J Cell Sci 110 ( Pt 23):2915-24 (1997) Renvall S,

Jarvinen M - "Energy metabolism of the peritoneal membrane in silica-induced peritonitis. A biochemical and enzyme histochemical study" Acta Chir Scand 146(3):177-83 (1980)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 6258364 & form=6 & db=m & Dopt=r Ruotsalainen M, Savolainen KM - "The role of G-proteins in the activation of human leukocytes by particulate stimuli to produce reactive oxygen metabolites" Toxicology99(1-2):67-76 (1995)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 7762003 & form=6 & db=m & Dopt=r(G proteins...) Rustin MH, Bull HA, Ziegler V, Mehlhorn J, Haustein UF, Maddison PJ, J, Dowd PM - "Silica-associated systemic sclerosis is clinically, serologically and immunologically indistinguishable from idiopathicsystemic sclerosis." Br J Dermatol 123(6):725-34 (1990)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 2176091 & form=6 & db=m & Dopt=r -Roman J,

Wichmann I, Salaberri J, Varela JM, Nunez-Roldan A - "Multiple Clinical and Biological Autoimmune Manifestations in 50 Workers after Occupational Exposure to Silica," Ann. Rheum. Dis. 52:534-538 (1993)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 8394065 & form=6 & db=m & Dopt=r Schiano A, Eisinger F, Detolle P, Laponche AM, Brisou B, Eisinger J - "Silicon, bone tissue and immunity" Rev Rhum Mal Osteoartic 46(7-9):483-6 (1979)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 9097232 & form=6 & db=m & Dopt=r Steenland K, Goldsmith DF - "Silica exposure and autoimmune diseases" Am J Ind Med 28(5):603-8 (1995)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 8561170 & form=6 & db=m & Dopt=r Suslikov VL, Semenov VD, Liashko LS - "Establishment of the maximum permissible concentration of silicic acid in drinking water" Gig Sanit (11):17-22 (1979) AO, Saffiotti U - "Transforming growth factor beta1, ras and p53 in silica-inducedfibrogenesis and carcinogenesis" Scand J Work Environ Health 21 Suppl 2:30-4 (1995)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 8929685 & form=6 & db=m & Dopt=r(G proteins) AO, Knapton AD, Ifon ET, Saffiotti U - "Transforming growth factor beta expression and transformation of rat lung epithelial cells by crystalline silica (quartz)" Int J Cancer 65(5):639-49 (1996)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 8598316 & form=6 & db=m & Dopt=r AO, Flanders KC, Saffiotti U - "Immunohistochemical localization of transforming growth factor-beta 1 in rats with experimental silicosis, alveolar type II hyperplasia, and lung cancer." Am J Pathol 142(6):1831-40 (1993)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 8389528 & form=6 & db=m & Dopt=r

Woodhead AD, Setlow RB, Pond V - "The Amazon molly, Poecilia formosa, as a test animal in carcinogenicity studies: chronic exposures to physical agents" Natl Cancer Inst Monogr 65:45-52(1984)http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 6087147 & form=6 & db=m & Dopt=r

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