A Case Report of possible human adjuvant disease

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Peer Review transcribed from handwritten notes

MEF000023972/1118

Article: A Case Report of possible human adjuvant

disease

Authors: Okano, Y; Nishikai, M; Sato, A

Date: 1984

Journal: ls of the Rheumatic Diseases, 1984,

43, 520-522

A case report of possible human adjuvant disease (an

anecdotal report about a Japanese woman developing

scleroderma, primary biliary cirrhosis, and Sjogren's

syndrome after cosmetic breast augmentation with

silicone injection)

The woman underwent breast augmentation w/silicone

injections in 1958 (at the age of 52). She was in

good health until 1974, at which time she developed

dry mouth. Three years later she developed swollen

stiff fingers and polyarthralgia; followed by

Raynaud's phenomenon, and by 1979 she had persistent

polyarthralgia and proximal scleroderma.

She also had hard, palpable masses beneath the breast

skin, moist rales were audible over the lower lung

fields bilaterally, her liver was enlarged and firm,

and the skin over her fingers, forearms, and face was

thick, tight, and pigmented. Laboratory test

indicated additional medical abnormalities, as well.

The author(s) interjected further discussion about the

other women (one Japanese). Since 1964 more than 30

patients with autoimmune disease-like syndromes and

some patients who developed classis collagen diseases

have been reported.

The author(s) used a table showing some of the

conditions developed by the patient, as a possible

result of breast augmentation with silicone

injections.