Total Platinum Concentration and Platinum Oxidation States in Body Fluids, Tissue, and Explants from Women . . .

April 7, 2006

Anal. Chem., ASAP Article 10.1021/ac0514016

S0003-2700(05)01401-0

Web Release Date: April 1, 2006

Total Platinum Concentration and Platinum Oxidation

States in Body Fluids, Tissue, and Explants from Women

Exposed to Silicone and Saline Breast Implants by

IC-ICPMS

E. D. Lykissa and S. V. M. Maharaj*

ExperTox, Inc., Deer Park, Texas 77536, and Center for

Research on Environmental Medicine, New Market,

land 21774

Received for review August 4, 2005. Accepted February

17, 2006.

Abstract:

Ion chromatography-inductively coupled plasma-mass

spectrometry was used to determine the total platinum

concentration and platinum oxidation states in samples

from women exposed to silicone and saline breast

implants. Samples included the following: whole blood,

urine, hair, nails, sweat, brain tissue, breast milk,

and explants. Mean Pt concentration in samples from

women exposed to silicone breast implants were as

follows: whole blood, 568.1 ± 74.77 pmol/L (n = 9);

urine, 1.77 ± 0.847 g/g of creatinine (n = 10); hair,

2.13 ± 2.984 ng/g (n = 9); nails, 0.88 ± 0.335 ng/g (n

= 9); sweat, 1.90 ± 1.691ng/g (n = 9); breast milk,

1.09 ± 0.316 g/L (n = 6). Pt in explanted silicone

breast implant gel (n = 9) occurred mainly in the +2,

+4, and +6 oxidation states. Pt in whole blood (n = 7)

and breast milk samples (n = 6) from women exposed to

silicone breast implants occurred mainly in the +2 and

+4 oxidation states. Saline breast implant fluid (n =

2) did not contain detectable levels of Pt. This is

the most comprehensive report, to date, to show that

women exposed to silicone breast implants have Pt

levels that exceed that of the general population, and

the first report, to date, to document the various Pt

oxidation states present in samples from women exposed

to silicone breast implants.

Recommended Posts