Magnesium and inflammation

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This was from that adrenal support group. Magnesium may be very, very important to us....as Rogene knows! Patty Arch Biochem Biophys. 2006 Apr 19;Magnesium and the inflammatory response: Potentialphysiopathological implications.Mazur A, Maier JA, Rock E, Gueux E, Nowacki W, Rayssiguier Y.Equipe Stress Metabolique et Micronutriments, Unite de NutritionHumaine UMR 1019, Centre de Recherche en Nutrition Humained'Auvergne, INRA, Theix, St. Genes Champanelle, France.The purpose of this review is to summarize experimental findingsshowing that magnesium modulates cellular events involved ininflammation. Experimental magnesium deficiency in the rat inducesafter a few days a clinical inflammatory syndrome characterized byleukocyte and macrophage activation, release of inflammatorycytokines and acute phase proteins, excessive production of freeradicals. Increase

in extracellular magnesium concentration,decreases inflammatory response while reduction in the extracellularmagnesium results in cell activation. Because magnesium acts as anatural calcium antagonist, the molecular basis for inflammatoryresponse is probably the result of modulation of intracellularcalcium concentration. The priming of phagocytic cells, the openingcalcium channel and activation of N-methyl-d-aspartate (NMDA)receptors, the activation of nuclear factor-kappa B (NFkappaB) havebeen considered as potential mechanisms. Moreover, magnesiumdeficiency induces a systemic stress response by activation of neuroendocrinological pathways. As nervous and immune systems interactbidirectionally, the roles of neuromediators have also beenconsidered. Magnesium deficiency contributes to an exaggeratedresponse to immune stress and oxidative stress is the consequence ofthe inflammatory response. Inflammation contributes to

the pro-atherogenic changes in lipoprotein metabolism, endothelialdysfunction, thrombosis, hypertension and explains the aggravatingeffect of magnesium deficiency on the development of metabolicsyndrome. Further studies are still needed to assess more accuratelythe role of magnesium in immune response in humans, but theseexperimental findings in animal models suggest that inflammation isthe missing link to explain the role of magnesium in manypathological conditions.PMID: 16712775 [PubMed - as supplied by publisher]__________________________________________________