Vitamin K1 Not Associated with Bone Mineral Density or Fracture Risk among Perimenopausal Women

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Intake of Vitamin K1 Not Associated with Bone Mineral Density or

Fracture Risk among Perimenopausal Women

Reference: “No effect of vitamin K(1) intake on bone mineral density

and fracture risk in perimenopausal women,” Rejnmark L, Vestergaard P,

et al, Osteoporos Int, 2006 May 9 [Epub ahead of print]. Department of

Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University

Hospital, Tage-Hansens Gade 2, Aarhus C, 8000, Denmark. E-mail:

rejnmark@... ).

Summary: In a study involving 2,016 perimenopausal women, intake of

vitamin K1 was not found to be associated with either bone mineral

density (BMD) or risk of fracture. Subjects were participants in the

Danish Osteoporosis Prevention Study (DOPS), and 50% were receiving

hormone replacement therapy during the time of the study. At baseline,

five years, and ten years, intake of vitamin K1 and BMD were recorded.

Dietary Vitamin K intake among subjects was close to that recommended by

the Food and Agriculture Association (60 mug/day). Occurrence of

fracture over the 10 year follow up period was also recorded. Results of

both longitudinal and cross-sectional analyses found no association

between intake of vitamin K and BMD of the femoral neck or lumbar spine.

Subjects in the top 5% of vitamin K1 intake did not have any significant

difference in BMD as compared to subjects in the lowest 5% of vitamin K1

intake. When comparing the vitamin K1 intake among the 360 subjects who

experien ced a fracture over the 10 year follow up period with the

vitamin K1 intake among the rest of the subjects, no significant

differences were found. The results of this study suggest that intake of

vitamin K1 may not be associated with either BMD or risk of fracture.

--

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