Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial

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Topic: Supplementation with Antioxidants with or without B-group

Vitamins Benefits Acute Ischemic Stroke Patients

Reference: “Antioxidant supplementation with or without B-group

vitamins after acute ischemic stroke: a randomized controlled trial,”

Ullegaddi R, Powers HJ, Gariballa SE, J Parenter Enteral Nutr., 2006;

30(2):108-14. (Address: Sheffield Institute for Nutritional Studies on

Ageing and the Human Nutrition Unit, University of Sheffield, Northern

General Hospital, Sheffield S5 7AU, UK).

Summary: In a randomized, controlled study involving 96 acute ischemic

stroke patients, within 12 hours of symptom onset, supplementation with

antioxidants including or excluding B-group vitamins was found to

mitigate oxidative damage, enhance antioxidant capacity, and exert an

anti-inflammatory effect. The patients were randomized to one of four

groups – 1) The antioxidant group (n = 24) received daily oral

supplementation with antioxidants (800 IU (727 mg) vitamin E and 500 mg

vitamin C) for 2 weeks; 2) The B-vitamin group (n = 24) received daily

oral supplementation with B-group vitamins (5 mg folic acid, 5 mg

vitamin B2, 50 mg vitamin B6, and 0.4 mg vitamin B12) for 2 weeks; 3)

The antioxidant plus B-vitamin group (n = 24) received daily oral

supplementation with antioxidants and B-group vitamins for 2 weeks; 4)

The control group (n = 24) received no supplementation for 2 weeks

(controls). Blood was obtained at baseline, day 7 and day 14, and

analyzed. Significant increases in plasma concentrations of vitamins C

and E, pyridoxal phosphate (B6 status), red blood cell folate, and

plasma total antioxidant capacity (TAOC), and improvements in red cell

glutathione reductase activation coefficient (a measure of B2 status)

were observed in the antioxidant, B-vitamin, and antioxidant plus

B-vitamin groups, compared with the control group. A nonsignificant

decline in plasma TAOC was observed in the control group. Additionally,

total plasma homocysteine (tHcy) concentrations decreased in the

B-vitamin and control groups, and increased in the antioxidant group.

C-reactive protein concentrations (CRP; a marker of tissue inflammation)

were significantly lower in the antioxidant, B-vitamin, and antioxidant

plus B-vitamin groups, compared with the control group. The antioxidant

plus B-vitamin group did not demonstrate any additive or synergistic

effects on any outcome measure. Thus, this study suggests that

supplementation with antioxidants with or without ! B-group vitamins

after acute ischemic stroke may mitigate oxidative damage, enhance

antioxidant capacity, and exert an anti-inflammatory effect.

--

ne Holden, MS, RD < fivestar@... >

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