Blood pressure response to calcium supplementation: a meta-analysis

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J Hum Hypertens. 2006 May 4; [Epub ahead of print]

Blood pressure response to calcium supplementation: a meta-analysis

of randomized controlled trials.

van Mierlo LA, Arends LR, Streppel MT, Zeegers MP, Kok FJ, Grobbee

DE, Geleijnse JM.

1Division of Human Nutrition, Wageningen University, Wageningen,

The Netherlands.

Calcium plays a role in blood pressure (BP) regulation, but the

importance of supplemental calcium intake for the prevention of

hypertension is still debated. We conducted a meta-analysis of

randomized controlled trials to determine the effect of calcium

supplementation on BP. A systematic search for randomized trials of

calcium supplementation and BP in non-pregnant subjects was performed in

Medline from 1966 to June 2003. Seventy-one trials were identified, 40

of which met the criteria for meta-analysis (total of 2492 subjects).

Two persons independently extracted data from original publications on

changes in calcium intake and BP. In addition, data were collected on

subjects' characteristics, that is, age, gender, initial BP and initial

calcium intake. A random effects model was used to obtain the effect of

calcium supplementation on BP, overall and in predefined population

subgroups. Calcium supplementation (mean daily dose: 1200 mg) reduced

systolic BP by -1.86 mm Hg (95% confidence interval: -2.91 to -0.81) and

diastolic BP by -0.99 mm Hg (-1.61 to -0.37). In people with a

relatively low calcium intake (</=800 mg per day) somewhat larger BP

estimates were obtained, that is, -2.63 (-4.03 to -1.24) for systolic BP

and -1.30 (-2.13 to -0.47) for diastolic BP. Our study suggests that an

adequate intake of calcium should be recommended for the prevention of

hypertension. More research on BP in people with calcium-deficient diets

is warranted.Journal of Human Hypertension advance online publication, 4

May 2006; doi:10.1038/sj.jhh.1002038.

PMID: 16673011 [PubMed - as supplied by publisher]

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