Inosine: Helps brain rewire itself after injury?

[Guest guest]

I saw some interesting stuff about inosine on another list and went

looking for more.

I've been stumbling across a lot of stuff..

In short, inosine may help with the kinds of injuries caused by

demyelination and inflammation.. which are similar to the kinds of

injuries caused by stroke...I think..

These are just two...

http://www.pnas.org/cgi/content/full/99/25/16303

Therapeutic intervention in experimental allergic encephalomyelitis by

administration of uric acid precursors

Gwen S. , Sergei V. Spitsin, Rhonda B. Kean, Tatiana Mikheeva,

Koprowski, and D. Craig Hooper *

Department of Microbiology and Immunology, Jefferson

University, Philadelphia, PA 19107

Contributed by Koprowski and approved October 23, 2002

http://www.pnas.org/cgi/content/abstract/99/13/9031

Inosine induces axonal rewiring and improves behavioral outcome after stroke

Peng Chen*,dagger ,Dagger , E. Goldberg*,Dagger , Kolb§,

Marc Lanser¶, and Larry I. Benowitz*,dagger ,||

* Department of Neurosurgery, Children's Hospital, 300 Longwood

Avenue, Boston, MA 02115; dagger Harvard Medical School, Boston, MA

02115; § Department of Psychology and Neuroscience, University of

Lethbridge, 4401 University Drive, Lethbridge, AB, Canada 11K 3M4; and

¶ Boston Life Sciences, Incorporated, 137 Newbury Street, Boston, MA

02116

Edited by M. Held, Massachusetts Institute of Technology,

Cambridge, MA, and approved May 2, 2002 (received for review February

7, 2002)

Cerebral infarct (stroke) often causes devastating and irreversible

losses of function, in part because of the brain's limited capacity

for anatomical reorganization. The purine nucleoside inosine has

previously been shown to induce neurons to express a set of

growth-associated proteins and to extend axons in culture and in vivo.

We show here that in adult rats with unilateral cortical infarcts,

inosine stimulated neurons on the undamaged side of the brain to

extend new projections to denervated areas of the midbrain and spinal

cord. This growth was paralleled by improved performance on several

behavioral measures.

Inosine may help heal mold-related injuries.. I think the chances of

it helping are pretty good..