Acute renal failure from inhalation of mycotoxins

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Titre du document / Document title

Acute renal failure from inhalation of mycotoxins

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Auteur(s) / Author(s)

DI PAOLO N. (1) ; GUARNIERI A. (1) ; LOI F. ; SACCHI G. ;

MANGIAROTTI A. M. ; DI PAOLO M. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Regional hosp. Siena, nephrology dialysis dep., 53100 Siena,

ITALIE

Résumé / Abstract

Mysterious deaths of archeologist after opening Egyptian tombs have

been suspected to be secondary to inhalation of mycotoxin, however,

the hypothesis has never been verified. Recently, we observed a case

of acute renal failure (ARF) undeniably due to inhalation of

ochratoxin of Aspergillus ochraceus. After spending 8 h in a granary

which had been closed for several months, a farmer and his wife

suffered temporary respiratory distress; 24 h later, the woman

developed nonoliguric ARF and biopsy revealed tubulonecrosis which

healed in 24 days.Toxic substances were not found, but a strain of

A. ochraceus producing ochratoxin was isolated from the wheat

Revue / Journal Title

Nephron (Nephron) ISSN 0028-2766 CODEN NPRNAY

Source / Source

1993, vol. 64, no4, pp. 621-625 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Karger, Basel, SUISSE (1964- 2002) (Revue)

Mots-clés anglais / English Keywords

Renal failure ; Female ; Tubulointerstitial nephritis ; Acute ;

Adult ; Etiology ; Mycotoxin ; Aspergillus ochraceus ;

Mycotoxicosis ; Diagnosis ; Human ; Urinary system disease ; Renal

disease ; Nephropathy ; Fungi Imperfecti ; Fungi ; Thallophyta ;

Inhalation ; Case study ; Experimental study ; Animal ;

Mots-clés français / French Keywords

Insuffisance rénale ; Femelle ; Néphropathie tubulointerstitielle ;

Aigu ; Adulte ; Etiologie ; Mycotoxine ; Aspergillus ochraceus ;

Mycotoxicose ; Diagnostic ; Homme ; Appareil urinaire pathologie ;

Rein pathologie ; Néphropathie ; Fungi Imperfecti ; Fungi ;

Thallophyta ; Inhalation ; Etude cas ; Etude expérimentale ;

Animal ;

002b14a05 ;

Mots-clés espagnols / Spanish Keywords

Insuficiencia renal ; Hembra ; Nefropatía tubulointersticial ;

Agudo ; Adulto ; Etiología ; Micotoxina ; Aspergillus ochraceus ;

Micotoxicosis ; Diagnóstico ; Hombre ; Aparato urinario patología ;

Riñón patología ; Nefropatía ; Fungi Imperfecti ; Fungi ;

Thallophyta ; Inhalación ; Estudio caso ; Estudio experimental ;

Animal ;

Localisation / Location

INIST-CNRS, Cote INIST : 11890, 35400003463057.0200