Guest guest Posted January 15, 2007 Report Share Posted January 15, 2007 This is EXTREMELY interesting to me. I was convinced that I was suffering from a cellular dysfunction, as all my symptoms pointed to a mitochondrial dysfunction, disruption in my ATP production, and metabolic acidosis, but thirty doctors would not listen to me, even when I told them about my exposure to Stachy. I finally found a doc that did a test proving it, and the results showed that the first stage of my Kreb's cycle was indeed blocked as a result of glutathione deficiency. (GSH is a co-factor in conversion of citric acid). GSH is also the body's main antioxidant, so my liver was using all available GSH for detoxing from mycosis, instead of for ATP production. you can't take GSH supps directly, as it does not survive transit in the GI tract, so I took GSH precursors like Lysine, Whey concentrate, Alpha-Lipoic Acid, Selenium, and lots of antioxidants to help my body to generate and recycle more GSH, as well as Co-q10 and L-Carnitine to help mito function and herbs for liver support. I was so incredibly sick for a year and a half that I had to stay with my parents, bedridden, unable to do anything, let alone work. Every system in my body was shutting down and no one could explain even one of my three pages of bizarre symptoms. I was in emergency four times and spent three days in hospital. I thought I'd never work again, or do any activity. Within three weeks of starting the protocol, I was feeling better, but still getting sick once a week or so. Now, after five months on the protocol, I'm back home, back to work full-time in my physically demanding job as a bartender in the Cayman Islands, swimming, hiking, doing photography, signing and playing guitar, etc etc, all the things I thought I'd never do again. I have no evidence of illness now for three months, aside from very occassional and mild muscle twitches and slight digestion issues that are resolving over time. There is no question that Stachy attacks cellular function; I just read an article last night on mycotoxins causing pores in red blood cells and, importantly for some of my symptoms, endothilial cells. Anyone who is suffering and would like to know more about my case and how I healed from it is most welcome to contact me. I have a TON of links and suggestions. carlsong@... Cheers!! . --- In , " wiedb " <wiedb@...> wrote: > > Our son, who has had a horrific experience with re-exposure, was put > on glutathione cream along with other nutrients. He's doing much > better - perhaps this research explains why. > > Mycotoxin-induced depletion of intracellular glutathione and altered > cytokine production in the human alveolar epithelial cell line > A549star, open > > L.N. Johannessena, Corresponding Author Contact Information, E-mail > The Corresponding Author, A.M. Nilsena and M. Løvika, b > > aDepartment of Cancer Research and Molecular Medicine, Faculty of > Medicine, Norwegian University of Science and Technology, N-7489 > Trondheim, Norway bDivision of Environmental Medicine, Norwegian > Institute of Public Health, Oslo, Norway > > Received 16 July 2006; revised 30 October 2006; accepted 2 November > 2006. Available online 15 November 2006. > > > Abstract > > Mould exposure has been associated with asthma and other inflammatory > airway conditions. However, cellular effects of inhaled mould > components are not well understood. We hypothesised that host defence > mechanisms, such as production of cytokines (TGF & #946;1, IL-6 and IL-8) and > the intracellular antioxidant glutathione (GSH), could be adversely > affected by different concentrations of mycotoxins. We studied the > effects of citrinin and gliotoxin on lipopolysaccharide > (LPS)-stimulated alveolar epithelial cells (A549). Cytokines in cell > culture supernatants were analysed by ELISA and levels of GSH were > measured by colorimetric (absorbance) determination. We found that GSH > decreased in a dose- and time-dependent manner when cells were exposed > to citrinin in particular. TGF & #946;1 was moderately reduced at low > mycotoxin concentrations but elevated at higher sub-toxic > concentrations. A tendency for an inverse relationship between TGF & #946;1 > and GSH levels was observed. IL-6 and IL-8 were not significantly > reduced at non-toxic mycotoxin concentrations. Thus, reduced > epithelial GSH and TGF & #946;1 levels combined with elevated IL-6 and IL-8 > levels may result in increased pro-inflammatory activity during > mycotoxin exposure. We suggest that this mechanism can contribute to > inflammation in mould exposure. > > Keywords: Indoor moulds; Mycotoxins; Inflammation; Oxidative stress; > Cytokines > > star, openThis work was done at the Department of Cancer Research and > Molecular Medicine. > Corresponding Author Contact InformationCorresponding author. Tel.: > +47 73 59 89 28; fax: +47 73 59 88 01. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 15, 2007 Report Share Posted January 15, 2007 WHOOPS! I made a slight error when mentioning glutathione precursors. I meant N-Acetyl Cysteine, not Lysine. Lysine is a Carnitine precursor I was also taking at the same time. Thanks, LiveSimply!--- In , " " <carlsong@...> wrote: > > This is EXTREMELY interesting to me. I was convinced that I was > suffering from a cellular dysfunction, as all my symptoms pointed to a > mitochondrial dysfunction, disruption in my ATP production, and > metabolic acidosis, but thirty doctors would not listen to me, even > when I told them about my exposure to Stachy. I finally found a doc > that did a test proving it, and the results showed that the first > stage of my Kreb's cycle was indeed blocked as a result of glutathione > deficiency. (GSH is a co-factor in conversion of citric acid). GSH is > also the body's main antioxidant, so my liver was using all available > GSH for detoxing from mycosis, instead of for ATP production. you > can't take GSH supps directly, as it does not survive transit in the > GI tract, so I took GSH precursors like Lysine, Whey concentrate, > Alpha-Lipoic Acid, Selenium, and lots of antioxidants to help my body > to generate and recycle more GSH, as well as Co-q10 and L-Carnitine to > help mito function and herbs for liver support. I was so incredibly > sick for a year and a half that I had to stay with my parents, > bedridden, unable to do anything, let alone work. Every system in my > body was shutting down and no one could explain even one of my three > pages of bizarre symptoms. I was in emergency four times and spent > three days in hospital. I thought I'd never work again, or do any > activity. Within three weeks of starting the protocol, I was feeling > better, but still getting sick once a week or so. Now, after five > months on the protocol, I'm back home, back to work full-time in my > physically demanding job as a bartender in the Cayman Islands, > swimming, hiking, doing photography, signing and playing guitar, etc > etc, all the things I thought I'd never do again. I have no evidence > of illness now for three months, aside from very occassional and mild > muscle twitches and slight digestion issues that are resolving over time. > There is no question that Stachy attacks cellular function; I just > read an article last night on mycotoxins causing pores in red blood > cells and, importantly for some of my symptoms, endothilial cells. > Anyone who is suffering and would like to know more about my case and > how I healed from it is most welcome to contact me. I have a > TON of links and suggestions. > carlsong@... > > Cheers!! > . > > > > Our son, who has had a horrific experience with re-exposure, was put > > on glutathione cream along with other nutrients. He's doing much > > better - perhaps this research explains why. > > > > Mycotoxin-induced depletion of intracellular glutathione and altered > > cytokine production in the human alveolar epithelial cell line > > A549star, open > > > > L.N. Johannessena, Corresponding Author Contact Information, E- mail > > The Corresponding Author, A.M. Nilsena and M. Løvika, b > > > > aDepartment of Cancer Research and Molecular Medicine, Faculty of > > Medicine, Norwegian University of Science and Technology, N-7489 > > Trondheim, Norway bDivision of Environmental Medicine, Norwegian > > Institute of Public Health, Oslo, Norway > > > > Received 16 July 2006; revised 30 October 2006; accepted 2 November > > 2006. Available online 15 November 2006. > > > > > > Abstract > > > > Mould exposure has been associated with asthma and other inflammatory > > airway conditions. However, cellular effects of inhaled mould > > components are not well understood. We hypothesised that host defence > > mechanisms, such as production of cytokines (TGF & #946;1, IL-6 and > IL-8) and > > the intracellular antioxidant glutathione (GSH), could be adversely > > affected by different concentrations of mycotoxins. We studied the > > effects of citrinin and gliotoxin on lipopolysaccharide > > (LPS)-stimulated alveolar epithelial cells (A549). Cytokines in cell > > culture supernatants were analysed by ELISA and levels of GSH were > > measured by colorimetric (absorbance) determination. We found that GSH > > decreased in a dose- and time-dependent manner when cells were exposed > > to citrinin in particular. TGF & #946;1 was moderately reduced at low > > mycotoxin concentrations but elevated at higher sub-toxic > > concentrations. A tendency for an inverse relationship between > TGF & #946;1 > > and GSH levels was observed. IL-6 and IL-8 were not significantly > > reduced at non-toxic mycotoxin concentrations. Thus, reduced > > epithelial GSH and TGF & #946;1 levels combined with elevated IL-6 and > IL-8 > > levels may result in increased pro-inflammatory activity during > > mycotoxin exposure. We suggest that this mechanism can contribute to > > inflammation in mould exposure. > > > > Keywords: Indoor moulds; Mycotoxins; Inflammation; Oxidative stress; > > Cytokines > > > > star, openThis work was done at the Department of Cancer Research and > > Molecular Medicine. > > Corresponding Author Contact InformationCorresponding author. Tel.: > > +47 73 59 89 28; fax: +47 73 59 88 01. > > > Quote Link to comment Share on other sites More sharing options...
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