alternatives for developmental neurotoxicity testing

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EHP

meeting report; alternatives for developmental neurotoxicity testing

<http://www.ehponline.org/members/2007/9841/9841.pdf>

<http://www.ehponline.org/docs/2007/9841/abstract.html>

keywords; alternatives,developmental neurotoxicity testing, human

science,in vitro models, policy, regulatory acceptance, screening,

Testsmart, the 3R's, validation

This strategy is based on the prevailing thought on the field that many

developmental neurotoxicants, regardless of their actual mechanism of

action, share common final outcomes of altered cell proliferation and

servival, aberrant cell differentiation or disrupted neuroal

connectivity.