Effect of Body Oxygen Levels on VEGF

[Guest guest]

Some followers of Dr Shoemaker protocols may be interested in this:

<http://ajp.amjpathol.org/cgi/content/full/154/3/823>

Hypoxia= low oxygen levels

Hyperoxia= high oxygen levels

Excerpt:

Hypoxia has been well established as a powerful stimulus for

increasing the abundance of VEGF mRNA in many tissues and cells

through both transcriptional and stability pathways.15-17 We

reported that hypoxia is a potent inducer of VEGF mRNA in ovine

pulmonary artery smooth muscle cells in vitro.18 Tuder et al

demonstrated up-regulation of VEGF and the VEGF receptors in rats

exposed to acute and chronic hypoxia.19 Although hypoxia is clearly

an important stimulus for VEGF, hyperoxia has not been as well

studied, but recent work suggests that it leads to decreased levels

of VEGF. For example, exposure of newborn rats to hyperoxia resulted

in decreased levels of VEGF in the retina with subsequent

endothelial cell death.20 We have previously examined rats exposed

to >95% FiO2 and found that there was a significant decrease in lung

VEGF mRNA as early as 24 hours, before the onset of clinical

symptoms.21