Guest guest Posted January 31, 2007 Report Share Posted January 31, 2007 Those DQ2 and DQ8 genes overlap extensively with the genotypes highlighted in Mold warriors as having a predisposition to be made ill when exposed to mold and have difficulty getting well after exposure. The DQ2 and DQ8 (which is a subtype of DQ3) are the main genes associated with celiac disease. Several of the other DQ genes are associated with gluten intolerance (including DQ1 and the other 2 subtypes of DQ3). That DQ8 is especially bad when you also have the DR4 (aka DRB1 of 4) as that's one of the " dreaded genotypes " . You can also have a DQ7 (gene associated with " gluten intolerance " rather than celiac per se) that is also bad when you have a DR4. The only DQ genotype that doesn't have a pre-disposition for reactions to gluten is DQ4. Shoemaker's biotoxin pathway diagram in Mold Warriors identifies the increased cytokines as a trigger for all these elevated antibodies. Shoemaker believes that it's the toxin exposure that triggers the gluten intolerance. Although, I personally believe that it's possible that it's the gluten intolerance that results in poor immune function that makes us more likely to become so ill upon exposure to mold and Lyme. However, I think it may well be a chicken and egg thing and it's likely impossibile to show what comes first for many folks given how ubiquitous mold is in our environments and gluten in our diets. I also think that both Shoemaker and Fine would benefit from looking at each other's research as I personally disagree with Shoemaker's viewpoint that once you get well, you can add gluten back to your diet (i.e., his view that this immune reaction to gluten isn't as extreme or any way related to celiac disease). Dr. Fine's view (and research supports) that a 100% gluten free diet is required for resolution of symptoms (and reduction in antibodies) in most situations. I know many that are on a gluten-free diet that attribute any health issues being due to inadvertent consumption of gluten, whereas I think it is highly likely in many cases that these folks also have had exposure to mold and other biotoxins. I read recently that the appropriate diet is 70% of wellness. That has certainly been my experience since being exposed both to Lyme and Mold - the gluten-free diet (and low carb/no sugar) has the biggest impact on my overall well-being. I've not at all had the experience that someone else mentioned that they can have small amounts of gluten (that may be because I have both a celiac gene and a gluten intolerant gene). Even minute amounts (e.g., fillers in prescription drugs) make me quite unwell (brain fog, etc.). B > > Dr Fine's research shows that approx 29% of people are gluten intolerant. This > is almost one in three. Celiac disease is an advanced form of gluten intolerance > when damage to the villi has occurred. Dr Fine says it is important to catch > gluten intolerance before it reaches the stage where damage has occurred. In > terms of the mechanism causing gluten intolerance and celiac disease there is no > difference. It is caused by the presence of anti-gliadin antibodies, which are > auto immune antibodies that can be formed by those who are genetically > determined to do so. A low MSH would appear to be one of the means which can > trigger the formation of these antibodies. HLA-DQ2 and/or HLA-DQ8 are genetic > markers for both stages of gluten intolerance and as such both stages are an > inherited autoimmune condition. The transcript of this talk by Dr Fine shows > that they are the same. > > > > HYPERLINK > " https://www.enterolab.com/StaticPages/EarlyDiagnosis.htm " https://ww w.enterolab. > com/StaticPages/EarlyDiagnosis.htm > Quote Link to comment Share on other sites More sharing options...
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