Immunotoxicity- xenobiotic -immune mediated hypersensitivity

[Guest guest]

Immunotoxicity can be divided into two broad research areas which are

mutyally exclusive.

1.Studies of altered hematopoietic(blood cell development) or

immunologic events associated with exposure of humans and animals to

chemicals-the immune system acts as a passive target(nonspecific) for

the xenobiotic, and the result may be an increased incidence or

severity of infectious disease or neoplasia because of the inability

to respond asequately to the invading agent.

2.Studies of immune-mediated hypersensitivity(allergy and

autoimmunity) resulting from exposure to environmental chemicals or

therapeutics. in hypersensitivity(i.e.allergy), the immune system

responds to small molecular weight compounds that bind to host

tissue, reconizing the complex as foreign antigen.

the immune responce to the chemical-host tissue complex may also lead

to disease, the most likely health consequences represented by

respiratory tract allergies(i.e. asthma,rhinitis) or allergic xontact

(skin) dermatitis. Autoimmunity, another form of immune-mediated

disease, is characterized by an immune responce against constituents

of the body's own tissues(autoantigens)

http://ntp.niehs.nih.gov/ntpweb/index.cfm?objectid=72015E7A-BDB7-CEBA-

F691195C3E208FF4

[Guest guest]

heres a easy link that might bring this up.

<http://ntp.niehs.nih.gov/go/9399>

mycotoxins noted.

also check out immunomodulation and hypersensativity on left,top of

page.

>

> Immunotoxicity can be divided into two broad research areas which

are

> mutyally exclusive.

>

> 1.Studies of altered hematopoietic(blood cell development) or

> immunologic events associated with exposure of humans and animals

to

> chemicals-the immune system acts as a passive target(nonspecific)

for

> the xenobiotic, and the result may be an increased incidence or

> severity of infectious disease or neoplasia because of the

inability

> to respond asequately to the invading agent.

>

> 2.Studies of immune-mediated hypersensitivity(allergy and

> autoimmunity) resulting from exposure to environmental chemicals or

> therapeutics. in hypersensitivity(i.e.allergy), the immune system

> responds to small molecular weight compounds that bind to host

> tissue, reconizing the complex as foreign antigen.

> the immune responce to the chemical-host tissue complex may also

lead

> to disease, the most likely health consequences represented by

> respiratory tract allergies(i.e. asthma,rhinitis) or allergic

xontact

> (skin) dermatitis. Autoimmunity, another form of immune-mediated

> disease, is characterized by an immune responce against

constituents

> of the body's own tissues(autoantigens)

>

> http://ntp.niehs.nih.gov/ntpweb/index.cfm?objectid=72015E7A-BDB7-

CEBA-

> F691195C3E208FF4

>