Acute inhalation toxicity of T-2 mycotoxin in mice.

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Acute inhalation toxicity of T-2 mycotoxin in mice.

Authors:

Creasia DA

Thurman JD

LJ 3rd

Nealley ML

York CG

Wannemacher RW Jr

Bunner DL

Source: Fundam Appl Toxicol. 1987, Feb; 8(2):230-5. [Fundamental and

applied toxicology : official journal of the Society of Toxicology]

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~vUnAFq:598

Abstract:

Experiments were conducted to study the acute inhalation toxicity of

T-2 mycotoxin in both young adult and mature mice. For a 10-min

aerosol exposure, the 24-hr LC50 of T-2 mycotoxin in young adult

mice was 0.08 +/- 0.04 mg T-2/liter air and that for mature mice was

0.325 +/- 0.1 mg T-2/liter air. Deaths among mice exposed to the

higher aerosol concentrations used in this study (i.e., 1.5 to 2.4

mg T-2/liter air) occurred in less than 5 hr. General clinical

symptoms in these animals immediately postexposure were tremors,

lethargy, stilted gait, and, in some animals, prostration. In

experiments separate from the concentration-response studies, total

deposition of T-2 aerosol and selective retention of T-2 in the

respiratory tract and nasal turbinates were determined analytically

from 3H-labeled T-2. When total deposition of T-2 was quantitated,

there was excellent agreement between that amount of T-2 deposited

and that amount of T-2 predicted from calculations based on aerosol

size and animal minute volume. Based on the aerosol deposition data,

the LD50 values of T-2 mycotoxins was 0.24 mg/kg for young adult

mice and 0.94 mg/kg for mature mice. For mice, inhalation of T-2

mycotoxin is at least 10 times more toxic than systemic

administration (LD50 approximately 4.5 mg/kg) and at least 20 times

more toxic than dermal administration (LD50 greater than 10 mg/kg).

Medical Subject Headings (MeSH):

Aerosols

Aging

Animals

Hydrogen-Ion Concentration

Male

Mice

Mice, Inbred ICR

Respiratory System/metabolism

Sesquiterpenes/*toxicity

T-2 Toxin/administration & dosage/metabolism/*toxicity

Tissue Distribution

CAS Registry Numbers:

Aerosols (0)

Sesquiterpenes (0)

T-2 Toxin (21259-20-1)

Language: English

International Standard Serial Number: 0272-0590 (Print)

Publication Types:

Comparative Study

Journal Article

Entry Month: 1987

Title Abbreviation: Fundam Appl Toxicol

Year of Publication: 1987

Last Revision Date: May 21, 1987

Medline Citation: NLM

Country: UNITED STATES

Citation Subset: IM

Medline Title Abbreviation: Fundamental and applied toxicology :

official journal of the Society of Toxicology

Stat: MEDLINE

Document Number: medline/3556834