Mycotoxins in Grains and Dust

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Mycotoxins in Grains and Dust

Authors:

Abramson D

Source: Principles of Health and Safety in Agriculture, J. A. Dosman

and D. W. Cockcroft, Editors; CRC Press, Inc., Boca Raton, Florida,

pages 125-127, 19 references, 1989

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~vUnAFq:464

Abstract:

Adverse health effects associated with exposures to mycotoxins

present in grains and dusts were reviewed. Mycotoxin producing

toxigenic fungi have been identified in field crops and crop storage

containers and they have been found to persist long after the fungi

that have produced them have died due to their low level of chemical

lability. The reported experimental 50% lethal doses of several

mycotoxins, including hepatotoxic aflatoxins, ochratoxin-A (303479),

citrinin (518752), sterigmatocystin (10048132), vomitoxin

(51481108), diacetoxysciropenol (2270408), and T-2 toxin (21259201)

were described. Three reported cases of disease induction in humans

thought be related to the inhalation of mycotoxins were described.

All three cases involved inhalation of aflatoxins. Subsequent

studies on aflatoxin levels in corn and other agricultural dusts

have demonstrated high airborne aflatoxin levels. No consistent

relationships have been seen between aflatoxin levels in the

airborne dust and those measured in bulk corn or between aflatoxin

levels and different particle sizes. The authors present

recommendations for future research in this area.

Keywords:

DCN-222155

Grain dusts

Organic dusts

Toxic effects

Health hazards

Occupational exposure

Agricultural workers

Farmers

Toxins

CAS Registry Numbers:

303-47-9

303-47-9

518-75-2

10048-13-2

51481-10-8

2270-40-8

21259-20-1

Entry Month: April, 1995

Year of Publication: 1989

Secondary Source ID: NIOSH/00222439

Document Number: NIOSH/00222439