Effect of fumonisin B1 on structure and function of macrophage plasma membrane.

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Effect of fumonisin B1 on structure and function of macrophage

plasma membrane.

Authors:

Ferrante MC

Meli R

Mattace Raso G

Esposito E

Severino L

Di Carlo G

Lucisano A

Author Address: Department of Pathology and Animal Health,

University of Naples Federico II, Via Delpino 1, 80137, Naples,

Italy.

Source: Toxicol Lett. 2002, Mar 28; 129(3):181-7. [Toxicology

letters]

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~vUnAFq:523

Abstract:

Fumonisin B1 (FB1), a mycotoxin produced by Fusarium moniliforme and

related fungi, is nephrotoxic, neurotoxic, hepatotoxic, carcinogenic

and immunosuppressive in animals and man. In this study we evaluate

the modifications of fluidity, endocytosis and peroxidative damage

of plasma membrane induced by FB1 in macrophage cell line J774A.1.

In these immune cells FB1 (1-10 microM) enhances membrane fluidity

and increases, time-dependently, the horseradish peroxidase (HRP)

endocytosis. This effect is concentration-dependent, significant at

10 microM, and reverted by IFN-gamma (100 U/ml). Moreover, FB1 (1-10

microM) induces a membrane peroxidative damage as evident by the

increase of malondialdehyde (MDA) production. All these mycotoxin

effects provide additional insight into potential mechanism by which

FB1, in macrophages, might enhance membrane damage and oxidative

stress contributing to the pathogenesis of mycotoxin induced

diseases.

Medical Subject Headings (MeSH):

Animals

Carboxylic Acids/*toxicity

Carcinogens, Environmental/*toxicity

Cell Line

Cell Membrane/*drug effects

Cell Survival/drug effects

Dose-Response Relationship, Drug

Drug Antagonism

Endocytosis/drug effects

*Fumonisins

Horseradish Peroxidase/pharmacokinetics

Interferon Type II/pharmacology

Lipid Peroxidation/drug effects

Macrophages/*drug effects/pathology

Malondialdehyde/metabolism

Membrane Fluidity/drug effects

Mice

Mycotoxins/*toxicity

Oxidative Stress

CAS Registry Numbers:

Carboxylic Acids (0)

Carcinogens, Environmental (0)

Fumonisins (0)

Mycotoxins (0)

fumonisin B1 (116355-83-0)

Malondialdehyde (542-78-9)

Interferon Type II (82115-62-6)

Horseradish Peroxidase (EC 1.11.1.-)

Language: English

International Standard Serial Number: 0378-4274 (Print)

Publication Types:

Journal Article

Research Support, Non-U.S. Gov't

Entry Month: December, 2002

Title Abbreviation: Toxicol Lett

Year of Publication: 2002

Last Revision Date: March 12, 2002

Medline Citation: NLM

Country: Netherlands

Citation Subset: IM

Medline Title Abbreviation: Toxicology letters

Stat: MEDLINE

Document Number: medline/11888701