Adrenal cortical necrosis caused by T-2 mycotoxicosis in female, but not male, m

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Adrenal cortical necrosis caused by T-2 mycotoxicosis in female, but

not male, mice.

Authors:

Thurman JD

Creasia DA

Quance JL

AJ

Source: Am J Vet Res. 1986, May; 47(5):1122-4. [American journal of

veterinary research]

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~vUnAFq:610

Abstract:

Experimentally, adrenal cortical parenchymal cell necrosis was

induced by T-2 mycotoxin in female, but not male, mice. The lesion

occurred in the adrenal glands in 11 of 11 female and 0 of 10 male

mice given a nose-only aerosol exposure to T-2 mycotoxin. The

necrosis, restricted to the zona fasciculata, began at the X zone

interface and extended peripherally to involve 15% to 70% of the

zone. Both light and transmission electron microscopies were used to

determine whether the cellular and subcellular damage involved

parenchymal cells of the zona fasciculata. Extensive necrosis of

cortical thymocytes and necrosis of lymphoid cells in follicles of

the spleen, lymph nodes, and intestine-associated lymphoid tissue

were observed in both sexes. This is the first report to describe

adrenal gland necrosis associated with exposure to T-2 mycotoxin.

Medical Subject Headings (MeSH):

Administration, Intranasal

Adrenal Cortex Diseases/*chemically induced/pathology

Animals

Female

Male

Mice

Mice, Inbred ICR

Mycotoxins/administration & dosage/*toxicity

Necrosis

Sex Factors

Thymus Gland/pathology

CAS Registry Numbers:

Mycotoxins (0)

Language: English

International Standard Serial Number: 0002-9645 (Print)

Publication Types:

Journal Article

Research Support, Non-U.S. Gov't

Entry Month: July, 1986

Title Abbreviation: Am J Vet Res

Year of Publication: 1986

Last Revision Date: July 7, 1986

Medline Citation: NLM

Country: UNITED STATES

Citation Subset: IM

Medline Title Abbreviation: American journal of veterinary research

Stat: MEDLINE

Document Number: medline/3717737