Trichothecenes/T-2 toxin

[Guest guest]

Good finds KC. As I understand it, T-2 toxin are Trichothecenes. But not

all Trichothecenes are T-2 Toxin. Trichothecenes have be found in water

damaged building materials. T-2 toxin have not. At least that is how I

understand

it.

Sharon K

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[Guest guest]

Trichothecenes

http://ull.chemistry.uakron.edu/erd/chemicals/11000/10245.html

Hazards and Protection.

Storage Keep in a cool, dry, dark location in a tightly sealed

container or cylinder. Keep away from incompatible materials,

ignition sources and untrained individuals. Secure and label area.

Protect containers/cylinders from physical damage.

Handling All chemicals should be considered hazardous. Avoid direct

physical contact. Use appropriate, approved safety equipment.

Untrained individuals should not handle this chemical or its

container. Handling should occur in a chemical fume hood.

Protection Chemical splash goggles in compliance with OSHA

regulations are advised; however, OSHA regulations also permit other

type safety glasses. Whre chemical resistant gloves. To prevent

repeated or prolonged skin contact, wear impervious clothing and

boots.

Respirators Use NIOSH/MSHA approved respirator appropriate for

exposure of concern.

Small spills/leaks Evacuate area and ventilate. Wear protective

equipment. If required, use an inert absrobent. Sweep up and place

in an appropriate container for disposal. Wash contaminated

surfaces.

Stability No data.

Incompatibilities Strong oxidizing agents.

Fire.

Fire fighting Wear a self-contained breathing apparatus in pressure-

demand, MSHA/NIOSH (approved or equivalent), and full protective

gear. During a fire, irritating and highly toxic gases may be

generated by thermal decomposition or combustion. Use agent most

appropriate to extinguish fire.

Health.

Exposure effects Headache and vertigo may be present.

Ingestion Anorexia, vomiting and diarrhea, which may be bloody,

may occur.

Inhalation Shortness of breath may occur.

Skin Contact with skin and eyes can cause coagulation necrosis.

First aid

Ingestion There are no known antidotes to trichothecene

mycotoxins. Treatments are directed at supporting hemopoietic

abnormalities, gastrointestinal damage, and skin damage. Activated

charcoal: administer charcoal as a slurry (240 ml water/30 g

charcoal). Usual dose: 25 to 100 g in adults/adolescents. Due to

gastrointestinal damage, fluid and electrolyte loss may be a

significant problem. Monitor electrolyte and fluid status and

replace as necessary. Hematopoietic abnormalities - monitor for

thrombocytopenia and leukopenia. Administer platelets or fresh

plasma as necessary. Consider filgrastim for severe neutropenia.

Antibiotics or isolation may also be necessary. Hypotension: infuse

10 to 20 ml/kg isotonic fluid, place in trendelenburg position. If

hypotension persists, administer dopamine (5 to 20 mcg/kg/min) or

norepinephrine (0.1 To 0.2 Mcg/kg/min), titrate to desired

response.

Inhalation Move patient to fresh air. Monitor for respiratory

distress. If cough or difficulty breathing develops, evaluate for

respiratory tract irritation, bronchitis, or pneumonitis. Administer

oxygen and assist ventilation as required. Treat bronchospasm with

beta2 agonist and corticosteroid aerosols.

Skin Remove contaminated clothing and wash exposed area

thoroughly with soap and water. A physician should examine the area

if irritation or pain persists.

Eyes Irrigate exposed eyes with copious amounts of tepid water

for at least 15 minutes. If irritation, pain, swelling, lacrimation,

or photophobia persist, the patient should be seen in a health care

facility.

Transport.

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T-2 toxin

http://ull.chemistry.uakron.edu/erd/chemicals/10000/9926.html

Hazards and Protection.

Storage Keep in a cool, dry, dark location in a tightly sealed

container or cylinder. Keep away from incompatible materials,

ignition sources and untrained individuals. Secure and label area.

Protect containers/cylinders from physical damage.

Handling All chemicals should be considered hazardous. Avoid direct

physical contact. Use appropriate, approved safety equipment.

Untrained individuals should not handle this chemical or its

container. Handling should occur in a chemical fume hood.

Protection Mycotoxins should be handled as very toxic substances.

Perform manipulations under hood whenever possible, & take

particular precautions, such as use of glove box, when toxins are in

dry form because of electrostatic nature & resulting tendency to

disperse in working areas. Mycotoxins.

Respirators Use NIOSH/MSHA approved respirator appropriate for

exposure of concern.

Small spills/leaks Evacuate area and ventilate. Wear protective

equipment. If required, use an inert absrobent. Sweep up and place

in an appropriate container for disposal. Wash contaminated

surfaces.

Stability Stable in the solid form.

Incompatibilities Strong oxidizing agents.

Fire.

Fire fighting Wear a self-contained breathing apparatus in pressure-

demand, MSHA/NIOSH (approved or equivalent), and full protective

gear. During a fire, irritating and highly toxic gases may be

generated by thermal decomposition or combustion. Use agent most

appropriate to extinguish fire.

Fire potential Fire: Toxins are not volatile but may be spread by

efforts to extinguish the fire. Toxins may be decomposed by heat to

produce other toxic gases. Toxins - dermally hazardous

Health.

Exposure effects Headache and vertigo may be present.

Ingestion Anorexia, vomiting and diarrhea, which may be bloody,

may occur.

Inhalation Shortness of breath may occur.

Skin Contact with skin and eyes can cause coagulation necrosis.

First aid

Ingestion Seek medical attention. If individual is drowsy or

unconscious, do not give anything by mouth; place individual on the

left side with the head down. Contact a physician, medical facility,

or poison control center for advice about whether to induce

vomiting. If possible, do not leave individual unattended.

Inhalation If symptoms develop, move individual away from

exposure and into fresh air. If symptoms persist, seek medical

attention. If breathing is difficult, administer oxygen. Keep person

warm and quiet; seek immediate medical attention.

Skin Remove contaminated clothing and wash exposed area

thoroughly with soap and water. A physician should examine the area

if irritation or pain persists.

Eyes Irrigate exposed eyes with copious amounts of tepid water

for at least 15 minutes. If irritation, pain, swelling, lacrimation,

or photophobia persist, the patient should be seen in a health care

facility.