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Re: oxidative stress,migranes,brain damage

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superoxide and NO produce (ONOO)oxidative stress

biology and superoxide: heywords SOD , ONOO,(martin pall)

super ocide is very toxic and is deployed by our immune systems to

kill invadeing microorganisms and phagocytes. we know that mycotoxin

exposure causes excessive nitric oxide production(iNOS).

superoxide reacts to nitric oxide produceing ONOO.as such, superoxide

is the main cause of oxidative stress.if the mitochondrail variant of

SOD is inactivated and suffers from multiple pathologies, including

reduced life span,liver cancer,muscle atrophy,cataracts and female

infertility

http://en.wikipedia.org/wiki/Superoxide

peroxvnitrate(ONOO) may contribute to the pathogenesis of cardiac

allograft rejection

http://ejcts.ctsnetjournals.org/cgi/content/abstract/26/2/276

its well documented that L-NMMA suppresses overproduction of NO

showing beneficial effects in various disease models includeing biral

infections,sepic shock and bacterial meningitis.

peroxvnitrate(ONOO) a product between nitric oxide and superoxide

anion plays a big role in development of post-bypass systemic

inflammatory responce.

ONOO is a potent oxident formed by a rapid reaction between NO and

superoxide anion.

http://ejcts.ctsnetjournals.org/cgi/content/abstract/26/2/276

>

> migranes cause brain damage

>

http://members.tripod.com/mueller_ranges/links/compendium/migraine.htm

l#

> mini_strokes)

>

> oxidative dtress leads to migranes

>

http://members.tripod.com/mueller_ranges/links/compendium/migraine.htm

l#

> oxidative_stress)

>

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Live, sounds like they are refering in part to ONOO. I heard on the

news that a study found that severe headackes,migranes are now knowm to

possibly be causeing brain damage. just cought the tail end but hrated

them say the migranes caused the oxidative stress and jnew it was the

other way around. I didn't spend alot of time loojing for what they

might have been citeing from or maybe thay misunderstood what they

read.I get a little aggervated when they state things as fact without

looking into it more because thats what the public hears. and I dont

believe I said that that oxidative stress was the only thing involved

in brain damage.

>

> It isn't just oxidative stress that leads to brain damage..

>

> This is new.

>

> Adult Hippocampal Neural Stem-Progenitor Cells in vitro are Vulnerable

> to the Mycotoxin Ochratoxin-A

>

> http://toxsci.oxfordjournals.org/cgi/content/abstract/kfm093v1

>

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