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Re: Re: Mold Neurotoxicity:Validity, Reliability and Baloney

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In a message dated 7/4/2007 6:27:09 P.M. Pacific Daylight Time,

gsgrl2000@... writes:

I guess this guy has never heard of Dr. Kaye Kilburn and for him

to say that adults have some sort of brain damage anyway doesn't

explain why my 13 year old has short term memory loss and has a worse

memory than me.

Lees-Haley can be found expounding his words of wisdom that symptoms of

environmental illnesses are all in people's heads for a very long time back.

Just search the UCSF tobacco legacy library. He is in with that crowd and

had been for a long time. Even his own peers have written papers calling his

Fake-Bad Scale, junk.

************************************** See what's free at http://www.aol.com.

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These are just the obvious ones where the scientists had the courage

to state the obvious..

There are lots of others where the information is there but you have

to put two and two together.

Adult Hippocampal Neural Stem-Progenitor Cells in vitro are Vulnerable

to the Mycotoxin Ochratoxin-A

Vasyl Sava, Velasquez, Shijie Song and -Ramos

http://toxsci.oxfordjournals.org/cgi/content/abstract/kfm093v1

Acute neurotoxic effects of the fungal metabolite ochratoxin-A

V. Sava O. Reunovaa, A. Velasqueza, R. Harbison and J. Sánchez-Ramos

http://dx.doi.org/10.1016/j.neuro.2005.07.004

The mechanisms of neurotoxicity induced by a Stachybotrys chartarum

Trichothecene Mycotoxin in an in vitro model

http://etd.lib.ttu.edu/theses/available/etd-05252005-163223/unrestricted/Karunas\

ena_Enusha_Diss.pdf

J Neurol Sci. 2006 Nov 1;249(1):68-75. Epub 2006 Jul 14.

Can low level exposure to ochratoxin-A cause parkinsonism?

Sava V, Reunova O, Velasquez A, -Ramos J.

University of South Florida, Tampa, FL 33612, USA.

Mycotoxins are fungal metabolites with pharmacological activities

that have been utilized in the production of antibiotics, growth

promoters, and other classes of drugs. Some mycotoxins have been

developed as biological and chemical warfare agents. Bombs and

ballistic missiles loaded with aflatoxin were stockpiled and may have

been deployed by Iraq during the first Gulf War. In light of the

excess incidence of amyotrophic lateral sclerosis (ALS) in veterans

from Operation Desert Storm, the potential for delayed neurotoxic

effects of low doses of mycotoxins should not be overlooked.

Ochratoxin-A (OTA) is a common mycotoxin with complex mechanisms of

action, similar to that of the aflatoxins. Acute administration of OTA

at non-lethal doses (10% of the LD(50)) have been shown to increase

oxidative DNA damage in brain up to 72 h, with peak effects noted at

24 h in midbrain (MB), caudate/putamen (CP) and hippocampus (HP).

Levels of dopamine (DA) and its metabolites in the striatum (e.g., CP)

were shown to be decreased in a dose-dependent manner. The present

study focused on the effects of chronic low dose OTA exposure on

regional brain oxidative stress and striatal DA metabolism. Continuous

administration of low doses of OTA with implanted subcutaneous Alzet

minipumps caused a small but significant decrease in striatal DA

levels and an upregulation of anti-oxidative systems and DNA repair.

It is possible that low dose exposure to OTA will result in an earlier

onset of parkinsonism when normal age-dependent decline in striatal DA

levels are superimposed on the mycotoxin-induced lesion.

Publication Types:

* Research Support, U.S. Gov't, Non-P.H.S.

PMID: 16844142 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve & db=pubmed & dopt=Abstract & li\

st_uids=16844142

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