Re: A Case Control Etiologic Study of Sarcoidosis

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http://dx.doi.org/10.1016/j.rmed.2006.08.005

*Respiratory Medicine*<http://www.sciencedirect.com/science/journal/09546111>

Volume 101, Issue

4<http://www.sciencedirect.com/science?_ob=PublicationURL & _tockey=%23TOC%237138%\

232007%23998989995%23647443%23FLA%23 & _cdi=7138 & _pubType=J & view=c & _auth=y & _acct=C\

000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=9f7902b2791017b3323e68769e0fb4\

62>,

April 2007, Pages 774-778

Antifungal treatment in sarcoidosis¡ªA pilot intervention trial

* *

*Marjeta

Tercelja<http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6WWS-4KXF2SB-\

3 & _user=10 & _coverDate=04%2F30%2F2007 & _rdoc=1 & _fmt= & _orig=search & _sort=d & view=c & _\

acct=C000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=f231bc05058cb8fbd5777db7\

e6e32345#aff1>,

[image: Corresponding Author Contact

Information]<http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6WWS-4KXF\

2SB-3 & _user=10 & _coverDate=04%2F30%2F2007 & _rdoc=1 & _fmt= & _orig=search & _sort=d & view\

=c & _acct=C000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=f231bc05058cb8fbd577\

7db7e6e32345#cor1>,

[image: E-mail The Corresponding Author] <marjeta.tercelj@...>, Tomaz

Rottb<http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6WWS-4KXF2SB-3 & _\

user=10 & _coverDate=04%2F30%2F2007 & _rdoc=1 & _fmt= & _orig=search & _sort=d & view=c & _acc\

t=C000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=f231bc05058cb8fbd5777db7e6e\

32345#aff2>and

Ragnar Rylander

c<http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6WWS-4KXF2SB-3 & _user\

=10 & _coverDate=04%2F30%2F2007 & _rdoc=1 & _fmt= & _orig=search & _sort=d & view=c & _acct=C0\

00050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=f231bc05058cb8fbd5777db7e6e3234\

5#aff3>

*

aUnit of Respiratory Diseases and Allergy, University Medical Center,

Clinical Center, Zaloska 7, 1525 Ljubljana, Slovenia

bInstitute of Pathology, Faculty of Medicine, University of Ljubljana,

Slovenia

cBiofact Environmental Health Research Center, Sweden

Received 6 March 2006; accepted 8 August 2006. Available online 18

September 2006.

Summary

Background

Sarcoidosis is generally treated with corticosteroids that are not always an

effective therapy.

Objectives

To assess if treatment with antifungal drugs would improve the clinical

status of patients with sarcoidosis.

Methods

Patients

(*n*=18<http://www.sciencedirect.com/science?_ob=MathURL & _method=retrieve & _udi=B\

6WWS-4KXF2SB-3 & _mathId=mml1 & _user=10 & _rdoc=1 & _acct=C000050221 & _version=1 & _userid\

=10 & md5=d524435be3c5a4fb7a59fcff471b4ebc>)

with sarcoidosis grades II and III according to established criteria and

without clinical and immunological signs of fungal infection, were treated

with antifungal medication together with corticosteroids for 3¨C6 months.

Pulmonary X-ray infiltration, lung function, and severity of symptoms were

registered before and after the treatment and at follow up 9¨C58 months

later.

Results

The treatment resulted in statistically significant decreases in the degree

of pulmonary infiltration with an average decrease in the group from 2.0 to

1.0. There were also significant increases in diffusion capacity and

decreases in the severity of symptoms.

Conclusion

It is suggested that treatment with antifungal drugs may be useful, at least

in certain cases of sarcoidosis.

*Keywords: *Fungi; Inflammation; Sarcoidosis; (1¡ú3)-*¦Â*-d-glucan;

Hypersensitivity

[image: Corresponding Author Contact

Information]<http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6WWS-4KXF\

2SB-3 & _user=10 & _coverDate=04%2F30%2F2007 & _rdoc=1 & _fmt= & _orig=search & _sort=d & view\

=c & _acct=C000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=f231bc05058cb8fbd577\

7db7e6e32345#bcor1>Corresponding

author. Tel.: +386 1522 2342.