A Case Control Etiologic Study of Sarcoidosis

[Guest guest]

A Case Control Etiologic Study of Sarcoidosis

Environmental and Occupational Risk Factors

http://ajrccm.atsjournals.org/cgi/reprint/170/12/1324

Lee S. Newman, Cecile S. Rose, Eddy A. Bresnitz, Milton D. Rossman,

na Barnard, Margaret Frederick,

L. Terrin, E. Weinberger, R. Moller, Geoffrey

McLennan, Hunninghake,

Louis DePalo, P. Baughman, C. Iannuzzi, Marc A.

Judson, Genell L. Knatterud,

Bruce W. , Alvin S. Teirstein, Henry Yeager, Jr., Carol J.

s†, L. Rabin,

A. Rybicki, Reuben Cherniack, and the ACCESS Research Group*

National Jewish Medical and Research Center and University of

Colorado Health Sciences Center, Denver, Colorado; New Jersey

Department

of Health and Senior Programs, Trenton, New Jersey; University of

Pennsylvania and Medical College of Pennsylvania-Hahnemann University

Medical Centers, Philadelphia, Pennsylvania; Clinical Trials and

Surveys Corp., and s Hopkins University School of Medicine,

Baltimore,

land; Beth Israel Deaconess Medical Center, Boston,

Massachusetts; University of Iowa College of Medicine, Iowa City,

Iowa; Mount

Sinai Medical Center, New York, New York; University of Cincinnati

Medical Center, Cincinnati, Ohio; University of South Carolina,

ton,

South Carolina; town University Medical Center, Washington,

DC; and Case Western Reserve University-Henry Ford Health Sciences

Center, Detroit, Michigan

Past research suggests that environmental factors may be associated

with sarcoidosis risk. We conducted a case control study to

test a priori hypotheses that environmental and occupational

exposures

are associated with sarcoidosis.

Conflict of Interest Statement :

L.S.N. does not have a financial relationship with

a commercial entity that has an interest in the subject of this

manuscript; C.S.R.

does not have a financial relationship with a commercial entity that

has an interest

in the subject of this manuscript; E.A.B. does not have a financial

relationship

with a commercial entity that has an interest in the subject of this

manuscript;

M.D.R. is the PI at the University of PA for a clinical trial of

infliximab in active

sarcoidosis and depending on patient recruitment could receive up to

$6,926 in

salary and extended benefits over the course of the contract with

Centocor; J.B.

does not have a financial relationship with a commercial entity that

has an interest

in the subject of this manuscript; M.F. does not have a financial

relationship with

a commercial entity that has an interest in the subject of this

manuscript; M.L.T.

does not have a financial relationship with a commercial entity that

has an interest

in the subject of this manuscript; S.E.W. does not have a financial

relationship

with a commercial entity that has an interest in the subject of this

manuscript;

D.R.M. does not have a financial relationship with a commercial

entity that has

an interest in the subject of this manuscript; G.M. does not have a

financial

relationship with a commercial entity that has an interest in the

subject of this

manuscript; G.H. does not have a financial relationship with a

commercial entity

that has an interest in the subject of this manuscript; L.D. does

not have a financial

relationship with a commercial entity that has an interest in the

subject of this

manuscript; R.P.B. does not have a financial relationship with a

commercial entity

that has an interest in the subject of this manuscript; M.C.I. does

not have a

financial relationship with a commercial entity that has an interest

in the subject

of this manuscript; M.A.J. received $3,000 in 2003 to function on

the medical

Advisory Board of Centocor; G.L.K. does not have a financial

relationship with a

commercial entity that has an interest in the subject of this

manuscript; B.W.T.

does not have a financial relationship with a commercial entity that

has an interest

in the subject of this manuscript; A.S.T. does not have a financial

relationship

with a commercial entity that has an interest in the subject of this

manuscript;

H.Y. does not have a financial relationship with a commercial entity

that has an

interest in the subject of this manuscript; C.J.J. deceased; D.L.R.

does not have a

financial relationship with a commercial entity that has an interest

in the subject

of this manuscript; B.A.R. does not have a financial relationship

with a commercial

entity that has an interest in the subject of this manuscript; R.C.

does not have

a financial relationship with a commercial entity that has an

interest in the subject

of this manuscript.

Acknowledgment : The authors thank Martyny, Ph.D., C.I.H. and

McCammon, Ph.D., C.I.H, for assisting in categorization of exposure;

Samet, M.D., B. Coultas, M.D., and Kathy Baumgartner, Ph.D.,

for advice

on questionnaire development; their patients, and the study

participants