BELLE Biological Effects Of Low Level Exposures

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BELLE Biological Effects Of Low Level Exposures

_http://www.belleonline.com/index.htm_ (http://www.belleonline.com/index.htm)

In May 1990, a group of scientists representing several federal agencies,

the International Society of Regulatory Toxicology and Pharmacology, the

private sector, and academia met to develop a strategy to encourage the

assessment

of the biological effects of low level exposures (BELLE) to chemical agents

and radioactivity. The meeting was convened because of the recognition that

most human exposures to chemical and physical agents are at relatively low

levels, yet most toxicological studies assessing potential human health effects

involve exposures to quite high levels, often orders of magnitude greater than

actual human exposures. Consequently, risks at low levels are estimated by

various means, frequently utilizing assumptions about which there may be

considerable uncertainty.

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