Scary abstract found while looking for info on mold immunotoxicity

[Guest guest]

Read this abstract.. this is new information..

This is about the immunotoxicity of 'nontoxic' (or so they claim)

stachybotrys strains that are low in 'macrocyclic' trichothecenes - It

seems that those strains turn out to be high in other mycotoxins,

atranones ('and sometimes simple trichothecenes, e.g., trichodermol

and trichodermin')

So they aren't nontoxic at all... they just have different toxins..

Comparison of Inflammatory Responses in Mouse Lungs Exposed to

Atranones A And C from Stachybotrys Chartarum

G. Rand, J. Flemming, J. , Taiwo O. Womiloju

DOI: 10.1080/15287390500360307

Journal of Toxicology and Environmental Health, Part A, Volume 69,

Issue 13 August 2006 ,

Abstract

Stachybotrys chartarum isolates can be separated into two distinct

chemotypes based on the toxins they produce. One chemotype produces

macrocyclic trichothecenes; the other produces atranones (and

sometimes simple trichothecenes, e.g., trichodermol and trichodermin).

Studies using in vivo models of lung disease revealed that exposure to

spores of the atranone producing S. chartarum isolates led to a

variety of immunotoxic, inflammatory, and other pathological changes.

However, it is unclear from these studies what role the pure atranone

toxins sequestered in spores of these isolates exert on lung disease

onset. This study examined dose-response (0.2, 1.0, 2.0, 5.0, or 20

b.mug atranone/animal) and time-course (3, 6, 24, and 48 h

postinstillation [PI]) relationships associated with inflammatory cell

and proinflammatory chemokine/cytokine responses in mouse lungs

intratracheally instilled with two pure atranones (either A or C)

isolated from S. chartarum. High doses (2.0 to 20 b.mug toxin/animal)

of atranone A and C induced significant inflammatory responses

manifested as differentially elevated macrophage, neutrophil,

macrophage inflammatory protein (MIP)-2, tumor necrosis factor (TNF)

and interleukin (IL)-6 concentrations in the bronchioalveolar lavage

fluid (BALF) of intratracheally exposed mice. Compared to controls,

BALF macrophage and neutrophil numbers were increased to significant

levels from 6 to 48 h (PI). Except for macrophage numbers in atranone

A treatment animals, cells exhibited significant dose dependent-like

responses. The chemokine/cytokine marker responses were significantly

and dose-dependently increased from 3 to 24 h PI and declined to

nonsignificant levels at 48 h PI. The results suggest not only that

atranones are inflammatory but also that they exhibit different

inflammatory potency with different toxicokinetics. Data also suggest

that exposure to these toxins in spores of S. chartarum in

contaminated building environments could contribute to inflammatory

lung disease onset in susceptible individuals.