Re: 2007 NEUROTOXICITY AND INFLAMMATION... DR. SUDAKIN

[Guest guest]

Jeanine,

That is a excellent paper you cite regarding the understanding of routes of

exposure that impact the brain.

_http://toxsci.http://toxsci.http://toxsci.<Whttp://tohttp://t_

(http://toxsci.oxfordjournals.org/cgi/content/abstract/98/2/526)

" Macrocyclic trichothecene mycotoxins produced by indoor air molds

potentially contribute to symptoms associated with damp building illnesses. The

purpose of this investigation was to determine (1) the kinetics of nasal

inflammation and neurotoxicity after a single intranasal instillation of

roridin A

(RA), a representative macrocyclic trichothecene; .... causing marked atrophy

of

olfactory epithelium.....there was marked bilateral atrophy of olfactory

nerve layer of the olfactory bulbs (OBs) of the brain.....and the

proinflammatory cytokines tumor necrosis factor...magnified RA-induced

proinflammatory gene

expression, apoptosis, and inflammation in the nasal tract. Taken together,

the results suggest that RA markedly induced FAS and proinflammatory

cytokine expression prior to evoking OSN apoptosis and OE atrophy and that RA's

effects were augmented by LPS. "

Dr. Sudakin,.

Perhaps you can explain to your fellow board members, how this

study supports your writing for the government funded American College of

Medical Toxicology paper, titled:

AMERICAN COLLEGE OF MEDICAL TOXICOLOGY COMMENT:

INSTITUTE OF MEDICINE REPORT ON DAMP INDOOR SPACES AND HEALTH

_https://www.acmt.net/main/page.asp?pageid=194_

(https://www.acmt.net/main/page.asp?pageid=194)

Can you tell us how a paper that finds " Macrocyclic trichothecene mycotoxins

produced by indoor air molds potentially contribute to symptoms associated

with damp building illnesses. "

Could be used to support your writing of, " With respect to mycotoxins in

indoor air, exposure modeling studies have concluded that even in moldy

environments, the maximum inhalation dose of mycotoxins is generally orders of

magnitude lower than demonstrated thresholds for adverse health

effects.(3,7,8) "

And why is it that the only other papers you were able to cite for your

above writing, were authored by your own employer, VeriTox? One that you cite

was outed on the front page of the Wall Street Journal, they other did not pass

a Kelley ruling just two months before you cited it for the ACMT. Surely,

as this is YOUR employer, YOU KNEW of this situation.

(3) American College of Occupational and Environmental Medicine. Evidence

Based Statement: Adverse Human Health Effects Associated with Molds in the

Indoor Environment. 2002. _http://www.acoem.org/guidelines/article.asp?ID=52_

(http://www.acoem.org/guidelines/article.asp?ID=52)

(7) Kelman BJ, Robbins CA, Swenson LJ, Hardin BD. Risk from inhaled

mycotoxins in indoor office and residential environments. Int J Toxicol 2004

January;23(1):3-10.

So how does the excellent paper Jeanine found support the exact opposite of

what it says? How does that work?

(8) Islam Z, Harkema JR, Pestka JJ. Satratoxin G from the black mold

Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in

the murine nose and brain. Environmental Health Perspectives. [online Feb 27,

2006] Available at _http://dx.doi.org/10.1289/ehp.8854_

(http://dx.doi.org/10.1289/ehp.8854) .

Instead of just lurking, perhaps it is time that you respond to those who

are ill after excessive mold exposure and explain your " science " to your fellow

board members.

Sharon

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[Guest guest]

The lipopolysaccharide (LPS) priming and potentiation is one of the many

things that you notice never get mentioned in any of their propaganda -

along with inhalation toxicity being higher than dermal absorbtion,

ingestion, or ip injection, fungal transport through buildings walls, the

growing body of information on fungal fragments, etc. - (they only use

spores.. as if spores were the whole story.)

Again and again and again they leave out important pieces of information

that have been discussed again and again..

So anyone who has any doubt as to their willful and irresponsible

'implausible denial' is being intentionally blind themselves..

There needs to be a law....