RE: Woman who died after gene therapy had infection

[Guest guest]

thats pretty sad, and scary and very interesting read on TNF

suppression and granulomas, I've omly found a few articles that

mention neutrophils found with granulomas. and if neutrophils are

found ir means they were there to fight a toxin but necrosis tnf was

suppressed or they wouldn't have found any neutrophils.

whem tnf is supressed granu;pmas disolve and release fungi.

thats very interesting, what happens than? is another granuloma

formed? does this just keep happening over and over when tnf is

suppressed? kind of like reaccuring infections?

and why would tnf even be a factor if the fungi was not toxic?

we know her's was.

and it has accured to me that granulomas only happen if the fragment

being attacked is toxic because if it's not only opoptis accurs and

it seems that if that caused granulomas everybody in the world would

be plagued with them.

--- In , " tigerpaw2c " <tigerpaw2c@...>

wrote:

>

> Woman who died after gene therapy had infection

> Bloomington Pantagraph - IL*

> By Rick Weiss

> Washington Post

>

>

http://www.pantagraph.com/articles/2007/08/17/news/doc46c66d64cc99579

> 7436510.txt

>

> WASHINGTON, D.C. — The 36-year-old McLean County native who died

> last month after being treated with an experimental gene therapy

was

> infected with a fungus that usually causes only a mild illness.

>

> But the infection spun out of control and ravaged her organs,

> suggesting that her immune system was seriously impaired, said a

> doctor who is part of the medical investigation.

>

> Jolee Mohr's body also was teeming with a cold-sore virus that the

> body normally keeps in check, another indication of a faltering

> immune system. And because of a tear inside her abdomen — perhaps

> caused by infection, perhaps by injury — she had an internal blood

> clot the size of a watermelon.

>

> No formal cause of death has been declared for Jolee Mohr, who died

> July 24.

>

> Mohr, a Bellflower native, and her husband Robb moved from McLean

> County in 1996 and had lived in ville since 2000. They have a

> 5-year-old daughter, Toree.

>

> Mohr had been generally healthy until July 2, when trillions of

> genetically engineered viruses were injected into her right knee in

> an experimental treatment for her rheumatoid arthritis.

>

> The injected viruses were genetically modified so they would

> suppress the immune system — which is responsible for the

> inflammation of rheumatoid arthritis — only in her knee. Doctors

> hope that tests on tissue specimens and blood samples will tell

> whether the treatment's effects somehow spread from the joint to

> other parts of Mohr's body.

>

> The picture will be complicated, however, because Mohr was also

> taking conventional immune-suppressing drugs for her arthritis. One

> of those in particular, adalimumab, whose brand name is Humira, is

> known to make patients susceptible to histoplasmosis, the kind of

> fungal infection that Mohr had. Inexplicably, Mohr suddenly became

> ill in July even though she had been taking that drug for years and

> the fungus that causes histoplasmosis is ubiquitous in the area

> where she lived.

>

> " It's a major mystery,'' said Hogarth, who heads the intensive

> care unit at the University of Chicago Medical Center, where Mohr

> was transferred days before she died.

>

> The company behind the medical experiment, Targeted Genetics of

> Seattle, has said that the treatment has an excellent safety record

> and that none of the more than 100 other volunteers who got the

> injections suffered anything more than short-lived side effects.

>

> Hogarth and about 20 other doctors and scientists are investigating

> the death with help from experts in an immune system factor called

> tumor necrosis factor-alpha, or TNF-alpha, which is suppressed by

> the experimental genetic treatment and by Humira.

>

> The autopsy was done with particular care, using sterile techniques

> more commonly associated with surgery on the living because of the

> importance of getting good clinical evidence, Hogarth said.

>

> " Think `CSI,' without the criminal implications,'' he said, adding

> that he suspects it will take one to two months to complete the

> tests.

>

> The fungus found throughout Mohr's body is Histoplasma capsulatum.

> It is common in airborne dust and bird droppings in the Mississippi

> and Ohio river valleys and generally causes a mild respiratory

> illness when inhaled. But in people whose immune systems are

> compromised — because of AIDS or cancer chemotherapy, for example —

> the fungal cells can spread to other organs and blossom quickly

into

> fatal infections.

>

> " It was in her liver. In the blood. It was essentially

everywhere,''

> Hogarth said.

>

> It is not known whether Mohr's infection was recently acquired or

> was old and recently reactivated. In healthy people, the immune

> system walls off the fungal cells in structures called granulomas,

> whose integrity is maintained by TNF-alpha. When TNF-alpha is

> suppressed, the granulomas can dissolve and release the still-

living

> fungi.

>

> Experts in gene therapy are eagerly awaiting the test results. A

> link to the death would be a painful setback for the research

field,

> which attempts to treat diseases by giving people new genes.

>

> " Gene therapy holds a great deal of potential,'' said Arthur

> Nienhuis of St. Jude Children's Research Hospital in Memphis, who

is

> president of the American Society of Gene Therapy. He noted that

> after more than a decade of failures and a handful of instances in

> which gene-based treatments caused leukemia in volunteers, the

> approach has recently produced what appear to be its first cures.

> More than a dozen children born with genetically defective immune

> systems are now living normal lives because of injections of new

> genes.

>

> A Targeted Genetics spokeswoman declined to comment on the autopsy

> findings, saying the company will make a full presentation at a

> National Institutes of Health meeting on Sept. 17.

>

[Guest guest]

This one hits close to home. I don't know the family but Bloomington

(the newspaper) is 25 miles from where I grew up. Bellflower is only

8 miles away, had 300 people, and was a high school sports rival

(long ago).

Carl Grimes

Healthy Habitats LLC

-----

> Woman who died after gene therapy had infection

> Bloomington Pantagraph - IL*

> By Rick Weiss

> Washington Post

>

> http://www.pantagraph.com/articles/2007/08/17/news/doc46c66d64cc99579

> 7436510.txt

>

> WASHINGTON, D.C. — The 36-year-old McLean County native who died

> last month after being treated with an experimental gene therapy was

> infected with a fungus that usually causes only a mild illness.

>

> But the infection spun out of control and ravaged her organs,

> suggesting that her immune system was seriously impaired, said a

> doctor who is part of the medical investigation.

>

> Jolee Mohr's body also was teeming with a cold-sore virus that the

> body normally keeps in check, another indication of a faltering

> immune system. And because of a tear inside her abdomen — perhaps

> caused by infection, perhaps by injury — she had an internal blood

> clot the size of a watermelon.

>

> No formal cause of death has been declared for Jolee Mohr, who died

> July 24.

>

> Mohr, a Bellflower native, and her husband Robb moved from McLean

> County in 1996 and had lived in ville since 2000. They have a

> 5-year-old daughter, Toree.

>

> Mohr had been generally healthy until July 2, when trillions of

> genetically engineered viruses were injected into her right knee in

> an experimental treatment for her rheumatoid arthritis.

>

> The injected viruses were genetically modified so they would

> suppress the immune system — which is responsible for the

> inflammation of rheumatoid arthritis — only in her knee. Doctors

> hope that tests on tissue specimens and blood samples will tell

> whether the treatment's effects somehow spread from the joint to

> other parts of Mohr's body.

>

> The picture will be complicated, however, because Mohr was also

> taking conventional immune-suppressing drugs for her arthritis. One

> of those in particular, adalimumab, whose brand name is Humira, is

> known to make patients susceptible to histoplasmosis, the kind of

> fungal infection that Mohr had. Inexplicably, Mohr suddenly became

> ill in July even though she had been taking that drug for years and

> the fungus that causes histoplasmosis is ubiquitous in the area

> where she lived.

>

> " It's a major mystery,'' said Hogarth, who heads the intensive

> care unit at the University of Chicago Medical Center, where Mohr

> was transferred days before she died.

>

> The company behind the medical experiment, Targeted Genetics of

> Seattle, has said that the treatment has an excellent safety record

> and that none of the more than 100 other volunteers who got the

> injections suffered anything more than short-lived side effects.

>

> Hogarth and about 20 other doctors and scientists are investigating

> the death with help from experts in an immune system factor called

> tumor necrosis factor-alpha, or TNF-alpha, which is suppressed by

> the experimental genetic treatment and by Humira.

>

> The autopsy was done with particular care, using sterile techniques

> more commonly associated with surgery on the living because of the

> importance of getting good clinical evidence, Hogarth said.

>

> " Think `CSI,' without the criminal implications,'' he said, adding

> that he suspects it will take one to two months to complete the

> tests.

>

> The fungus found throughout Mohr's body is Histoplasma capsulatum.

> It is common in airborne dust and bird droppings in the Mississippi

> and Ohio river valleys and generally causes a mild respiratory

> illness when inhaled. But in people whose immune systems are

> compromised — because of AIDS or cancer chemotherapy, for example —

> the fungal cells can spread to other organs and blossom quickly into

> fatal infections.

>

> " It was in her liver. In the blood. It was essentially everywhere,''

> Hogarth said.

>

> It is not known whether Mohr's infection was recently acquired or

> was old and recently reactivated. In healthy people, the immune

> system walls off the fungal cells in structures called granulomas,

> whose integrity is maintained by TNF-alpha. When TNF-alpha is

> suppressed, the granulomas can dissolve and release the still-living

> fungi.

>

> Experts in gene therapy are eagerly awaiting the test results. A

> link to the death would be a painful setback for the research field,

> which attempts to treat diseases by giving people new genes.

>

> " Gene therapy holds a great deal of potential,'' said Arthur

> Nienhuis of St. Jude Children's Research Hospital in Memphis, who is

> president of the American Society of Gene Therapy. He noted that

> after more than a decade of failures and a handful of instances in

> which gene-based treatments caused leukemia in volunteers, the

> approach has recently produced what appear to be its first cures.

> More than a dozen children born with genetically defective immune

> systems are now living normal lives because of injections of new

> genes.

>

> A Targeted Genetics spokeswoman declined to comment on the autopsy

> findings, saying the company will make a full presentation at a

> National Institutes of Health meeting on Sept. 17.

>

>

>

>

> FAIR USE NOTICE:

>

>

>

[Guest guest]

Here is a paper that shows how toxins like satratoxin when combined with

bacterial endotoxins common in damp buildings induce tnf-alpha

overexpression especially when endotoxins like LPS are present (satratoxin

is in stachybotrys) and tnf-alpha is known to be involved in granuloma

formation, so this synergism could be part of the picture for many

inflammatory diseases..

Toll-Like Receptor Priming Sensitizes Macrophages to Proinflammatory

Cytokine Gene Induction by Deoxynivalenol and Other Toxicants *

Pestkaand Hui-Ren

Zhou*

http://toxsci.oxfordjournals.org/cgi/content/full/92/2/445

Toxicological Sciences 2006 92(2):445-455; doi:10.1093/toxsci/kfl012

Activation of the innate immune system might predispose a host to

toxicant-induced inflammation. *In vitro* macrophage models were employed to

investigate the effects of preexposure to Toll-like receptor (TLR) agonists

on induction of proinflammatory cytokine gene expression by the

trichothecene mycotoxin deoxynivalenol (DON) and other toxicants. Priming of

the murine RAW 264.7 macrophage line or peritoneal murine macrophages with

the TLR4 agonist lipopolysaccharide (LPS) at 100 ng/ml for 4, 8, and 16 h

significantly increased DON-induced IL-1ß, IL-6, and TNF-[image:

{alpha}]mRNA expression as

compared to LPS or DON alone. The minimum LPS concentration for

sensitization of both cell types was 1 ng/ml. LPS priming also potentiated

IL-1ß mRNA induction by DON in human whole-blood cultures, suggesting the

relevance of the murine findings. As observed for LPS, preexposure to TLR

agonists including zymosan (TLR2), poly (I:C) (TLR3), flagellin (TLR5), R848

(TLR7/8), and ODN1826 (TLR9) sensitized RAW 267.4 cells to DON-induced

proinflammatory

gene expression. Amplified proinflammatory mRNA expression was similarly

demonstrated in LPS-sensitized RAW 264.7 cells exposed to the microbial

toxins satratoxin G, Shiga toxin, and zearalenone as well as the

anthropogenic toxicants nickel chloride, triphenyltin,

2,4-dinitrochlorobenzene, and 2,3,7,8-tetrachlorodibenzodioxin. The results

suggest that prior TLR activation might render macrophages highly sensitive

to subsequent induction of proinflammatory gene expression by xenobiotics with

diverse mechanisms of action.

[Guest guest]

That's ridiculous to deliberately suppress the immune system. The

whole health care rational of suppressing our bodily systems gone

haywire. Everything they do is to suppress the way of body

functions (anti-*everything), after it has evolved for billions of

years in a particular way, each evolution designed to help us to

survive. Everything the body does is to survive. Do these people

even understand how the body works or have any respect nature? Do

they think our bodies are totally and fatally flawed in the way they

were designed in the first place? In that case, how is it we have

evolved to highest form of life? I don't believe that arthritis is

an autoimmune dysfunction either. The body is probably attacking a

pathogen as it should and they just either don't know which pathogen

it is, or this is the ultimate cover up of fungus, pretending if the

body is attacking it, it is attacking nothing. No wonder woman

died. Would they have done this to someone in their own family with

arthritis? Do these people who arranged this have any arthritis and

tried it themselves?? Of course not. They aren't stupid. They are

just selfish and evil.

--- In , " tigerpaw2c " <tigerpaw2c@...>

wrote:

>

> Woman who died after gene therapy had infection

> Bloomington Pantagraph - IL*

> By Rick Weiss

> Washington Post

>

>

[Guest guest]

the immune system is supressed to stop the inflamation, problem is

that supressing the immune system makes you more vonerable to other

infectious agents.

this is a pretty good reason why cause should be detutmined and dealt

with instead of just treating symptoms, but gee, that would put the

drug industry out on the street wouldn't it.

>

> That's ridiculous to deliberately suppress the immune system.

[Guest guest]

This is why I don't understand why they treat cancer by suppressing

the immune system or why anyone would agree to it.

I was talking to this guy I met who said he developed arthritis when

he was real young but as he told his story it all added up to fungi,

in my opinion, anyway. My mom has also developed arthritis and at the

same time my grandmother, her mom, who lives with her at the late age

of 90 developed Alzheimeer's. They both have the exact same symptoms

except my mom was diagnosed with arthritis and my grandmother was

diagnosed with Alzheimer's but I believe it's mold but they won't

listen. They keep listening to the same doctors.... I'm ranting but

you get the picture. In other words, I'm agreeing with you.

>

> That's ridiculous to deliberately suppress the immune system.

[Guest guest]

a few things about this article seem a little off to me. like takeing

something for years with no problem than all the sudden it's brought up

as possable cause of contracting something thats well known to be in

your inviroment.

[Guest guest]

Thats the way defense lawyers win cases, by doing things like that. They

want the jury to blame that instead of the new therapy.

For example, i read today that even though 45,000 legal cases have been

brought by families that had a member get a heart attack or stroke after

taking Vioxx, not a single plaintiff has seen a penny from any of the

lawsuits yet, even though several have 'won'. They are all being appealed

and the defense lawyers drag it on to take decades.. Most people don't have

the energy to fight on, die or whatever. The US is not a friendly climate

for product liability lawsuits because of the way our appeal system works.

the tobacco companies showed this to be a big weakness of our legal system.

Each lawsuit, appeal, etc. takes lawyers..money, time..

Plaintiffs Find Payday Elusive in Vioxx

Cases<http://www.nytimes.com/2007/08/21/business/21merck.html?ref=health>

http://www.nytimes.com/2007/08/21/business/21merck.html?ref=health

By ALEX BERENSON

None of the 45,000 people who have sued Merck over heart attacks or strokes

suffered after taking Vioxx have received payments from the company.

>On 8/21/07, who <jeaninem660@...> wrote:

>

> a few things about this article seem a little off to me. like takeing

> something for years with no problem than all the sudden it's brought up

> as possable cause of contracting something thats well known to be in

> your inviroment.

>

> __

>

[Guest guest]

true, it really seems that there should be a SOL's on injury cases to

forse the whole process to be dealt with in a timely manner.

nothing like committing murder and getting away with it. maybe if it

was considered criminal like it should be, someone setting in jail

might make things move a little faster.

whats the difference in exposing someone to something toxic and

hitting them upside the head with a base ball bat. injury is injuty.

In , LiveSimply <quackadillian@...>

wrote:

>

> Thats the way defense lawyers win cases, by doing things like that.

[Guest guest]

>true, it really seems that there should be a SOL's on injury cases to

forse the whole process to be dealt with in a timely manner.

But people still get injured and then they have to sue to get redress and

that usually means they have to pay a lawyer and most people can't afford to

do that so it means that most people who do it get away with it, especially

the ones who make it a practice of only picking on the poor and weak.. they

get away scot free..

>nothing like committing murder and getting away with it. maybe if it

was considered criminal like it should be, someone setting in jail

might make things move a little faster.

Right now mold injuries are considered to be civil torts which means that

the people who commit them are not considered to be criminals, nomatter how

much people are hurt. Even if they die, they would have to sue to get

justice..

Hows that for logic?

>whats the difference in exposing someone to something toxic and

hitting them upside the head with a base ball bat.

If you hit someone with a baseball bat then its assault. But there are no

standards for toxic mold exposure in the US so any level of toxic mold

nomatter how toxic, is legal.

>injury is injuty.

Not in the US. In fact, several laws make special exceptions for toxic mold.

For example, California's Prop 65 specifically exempts toxic mold from

being warned about, even though they by doing that implicity admit that it

is toxic...

[Guest guest]

I might be wrong, but I think the gene therapy company might be the same as

“you know who”.

Love, Bruce

_____

From: [mailto: ]

On Behalf Of tigerpaw2c

Sent: Monday, August 20, 2007 12:36 PM

Subject: [] Woman who died after gene therapy had infection

Woman who died after gene therapy had infection

Bloomington Pantagraph - IL*

By Rick Weiss

Washington Post

http://www.pantagra

<http://www.pantagraph.com/articles/2007/08/17/news/doc46c66d64cc99579>

ph.com/articles/2007/08/17/news/doc46c66d64cc99579

7436510.txt

WASHINGTON, D.C. — The 36-year-old McLean County native who died

last month after being treated with an experimental gene therapy was

infected with a fungus that usually causes only a mild illness.

But the infection spun out of control and ravaged her organs,

suggesting that her immune system was seriously impaired, said a

doctor who is part of the medical investigation.

Jolee Mohr's body also was teeming with a cold-sore virus that the

body normally keeps in check, another indication of a faltering

immune system. And because of a tear inside her abdomen — perhaps

caused by infection, perhaps by injury — she had an internal blood

clot the size of a watermelon.

No formal cause of death has been declared for Jolee Mohr, who died

July 24.

Mohr, a Bellflower native, and her husband Robb moved from McLean

County in 1996 and had lived in ville since 2000. They have a

5-year-old daughter, Toree.

Mohr had been generally healthy until July 2, when trillions of

genetically engineered viruses were injected into her right knee in

an experimental treatment for her rheumatoid arthritis.