Subchronic toxicity study of (ingested) trichothecene

[Guest guest]

I am thinking that this is a new study on chronic effects of a

trichothecene.. I had not seen it before.

my thoughts are that its on an ingestion situation and the mycotoxin

is a fusarium family trichothecene toxin.. but it shows that the

OBSERVED no adverse effect level is (how much?) I think substantially

lower than the levels typically used by the people who claim mold

illness is impossible and that toxinogenic molds don't damage health.

(I am trying to remember where I saw levels given but it was recently

and it was mentioned on here, I think)

And as has been much discussed, inhaled trichothecene mycotoxins have

been shown to be substantially more toxic - sometimes by many times,

than ingested ones, by weight. Or - 'Inhalation is an efficient mode

of toxin delivery' they would say in a biowarfare scenario.

(But this important fact has conspicuously never been mentioned in an

ACOEM or AAAAI official pontifications on the subject, which I think

is such a conspicuous scientific sin of major omission that even just

that - poisons their legitimacy right there)

Also, what about dermal absorbtion. All of that exposure - adds up -

to make people sick.

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Food Chem Toxicol. 2007 Jul 18; [Epub ahead of print]

A 90-day subchronic toxicity study of nivalenol, a trichothecene

mycotoxin, in F344 rats.

Takahashi M, Shibutani M, Sugita-Konishi Y, Aihara M, Inoue K, Woo

GH, Fujimoto H, Hirose M.

Division of Pathology, National Institute of Health Sciences,

1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.

A subchronic toxicity study of nivalenol (NIV), a trichothecene

mycotoxin, was conducted in male and female F344 rats fed diet

containing 0, 6.25, 25 or 100ppm concentration for 90 days. Decrease

of body weight and loose stools were observed at 100ppm in both sexes

from the start of the experiment, and body weight reduction was also

observed at 25ppm in males from week 6. At necropsy, many organs

demonstrated reduced absolute weights at 100ppm in both sexes, mostly

due to the reduction in the body growth, with reduction of relative

thymus weight also being evident in females. Hematologically, decrease

of the white blood cell count was found at 100ppm in males and from

6.25ppm in females. In addition, decreased platelet counts in both

sexes, red blood cell counts in males, and the hemoglobin

concentration in females were detected at 100ppm. Histopathologically,

treatment-related changes were predominantly observed in the

hematopoietic and immune organs and the anterior pituitary in both

sexes and female reproductive organs at 100ppm, such as thymic

atrophy, hypocellularity in the bone marrow, diffuse hypertrophy of

basophilic cells with increase of castration cells in the anterior

pituitary, and increase of ovarian atretic follicles. Based on the

hematological data, the no-observed-adverse-effect level of NIV was

determined to be less than 6.25ppm (0.4mg/kg body weight/day for both

males and females).

PMID: 17765382 [PubMed - as supplied by publisher]