Control Strategies For Fungal Contamination In Cleanrooms

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Control Strategies For Fungal Contamination In Cleanrooms

By: Carol Bartnett, Jim Polarine, and Lopolito

September 2007

Pharmaceutical, biotech, and medical device clean-rooms today are faced with

the increasing prevalence of molds that can lead to environmental monitoring

excursions. Over the years, we have noticed mold issues associated with

cleanrooms, cold rooms, door kick plates, incubators, and cleanroom startups.

Molds, such as Aspergillus, have come from many sources in the cleanroom, such

as bags, boxes, markers, intervention equipment, and cart wheels. These

occurrences seem to be more prevalent. Aspergillus, Penicillium, Trychophyton,

and

other molds have, in some cases, caused significant microbial excursion

issues that have resulted in adverse impacts on production.

This article will provide an overview of the different types of fungi,

killing mechanisms of several of the germicides commonly available, selection

criteria for disinfectants, test methods, and recommendations for reducing the

likelihood of environmental excursions due to molds.....

_http://www.cemag.us/articles.asp?pid=696_

(http://www.cemag.us/articles.asp?pid=696)

Sharon

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