Study examines toxic effects of stachybotrys metabolites on lung cells

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I had not seen this study before. It seems as if there is often a

delay of several months before they show up in PubMed's database.

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Altern Lab Anim. 2007 Mar;35(1):47-52.Links

An in vitro study of the toxic effects of Stachybotrys chartarum

metabolites on lung cells.

Kováciková Z, Tátrai E, Piecková E, Tulinská J, Pivovarová Z,

Matausic-Pisl M, Kuricová M, Wsolová L.

Research Base of Slovak Medical University, Bratislava, Slovakia.

zuzana.kovacikova@...

During a study of indoor fungal colonisation, several isolates of

Stachybotrys chartarum were recovered, and the effects of metabolites

from four isolates on lung epithelial Type II cells and alveolar

macrophages were studied in vitro. All the isolates showed toxic

effects on both cell types, and they differed only in the extent of

the changes induced. In Type II cells, the number of alkaline

phosphatase positive cells was reduced, the pattern of Maclura

pomifera agglutinin (MPA) binding was changed, and acid phosphatase

activity in alveolar macrophages was diminished. In both cell types,

the production of monocyte chemotactic protein-1 (MCP-1) and tumour

necrosis factor-alpha (TNF-alpha) was changed, and parameters related

to antioxidant status (superoxide dismutase, glutathione peroxidase,

glutathione) were decreased.

PMID: 17411351 [PubMed - indexed for MEDLINE]