Proteomic and the detection of molds

[Guest guest]

Hi All,

I wanted to alert you to this new technology that has been in

existance for since 2002. I became interested in this company

because I am so high risk for breast & ovarian cancers. Now they

have a patent on a test to detect mold in the body. In keeping with

the honesty we all know exists at the CDC, NIH, NCI and the FDA this

product is hung up waiting for approval from the FDA. Here's their

website.

http://www.correlogic.com/newsandevents/index.php

June 2006

The June 2006 issue of the peer-reviewed journal, Biomolecular

Engineering, published " Novel technology for rapid species-specific

detection of Bacillus spores " . Correlogic's Dr. Mansfield, Dr.

Ping Yip and Dr. Ben Hitt, and colleagues from the Stark

Draper Laboratory and Tufts University School of Medicine are authors

of this paper. Using pyrolysis-micromachined differential mobility

spectrometry (DMS) and Correlogic's ProteomeQuest® software to

provide a fingerprint that identifies each species, researchers were

able to distinguish among bacillus species closely related to

Bacillus anthracis (the causative agent in anthrax). Results showed

over 90 percent accuracy with a sensitivity of detection of 5,000

spores, significantly below the median infectious dose of 8,000 to

10,000 spores and well below the median lethal dose of ~62,000

spores. Few existing rapid detection techniques detect below 100,000

spores. Together with our collaborators we continue to identify an

optimal fingerprint that will be present in a spore sample regardless

of concentration, growth media, or interferents that may be present.

In a post 9/11 environment, there is urgent need for tools to detect

bio-warfare agents with high specificity. The powerful combination of

the DMS machine and Correlogic's technology shows promise for

portable, near-real-time accurate detection of spores. In a more

generalized setting, it may also be possible to detect and identify

other harmful bacteria such as the Clostridia, which cause tetanus,

diarrhea, botulism and food poisoning.

March 16, 2006

Our work was also presented as a poster " Detection and

Differentiation of Bacillus Spores Using Pyrolysis: Differential

Mobility Spectrometry and Genetic Algorithms " at the Pittcon Homeland

Security and Forensics session, March 16, 2006.

September 15, 2005

The September 15, 2005 issue of the peer-reviewed journal Analytical

Chemistry publishes " Species-Specific Bacteria Identification Using

Differential Mobility Spectrometry and Bioinformatics Pattern

Recognition " . Mansfield, Correlogic's VP for Research and

Development, is one of the two co-first authors, and Correlogic's Ben

Hitt and Ping Yip are also co-authors of the paper. The collaboration

involved Stark Draper Labs, Massachusetts General Hospital

and others. Scientists used a portable, micromachined differential

mobility spectrometer in conjunction with Correlogic's " Hidden

Patterns " and Proteome Quest technology, to identify and

differentiate between live bacteria based on analysis of the gases

given off by the growing bacterial cultures. The results have

implications for diagnosis of bacterial infections using breath

analysis. Other applications may include detection and identification

of microbial growth in building materials and veterinary uses.

August 15, 2005

The US Patent and Trademark Office grants " Hidden Patterns " patent.

The invention – a process for using pattern recognition technology to

evaluate subtle patterns of molecular changes in a patient's body --

is at the core of Correlogic's tests for the early detection of

various cancers and other diseases, and at the core of much research

underway throughout the field of proteomics. The patent grants broad

protection to the spectrum of biological applications, including

disease detection, drug efficacy and toxicity, staging, prognosis and

others. Read the press release.