Re: Antibody Response to Long-term and High-dose Mould-expose...

[Guest guest]

Great find, KC!

" Increasing levels of mould-specific IgG1, IgG2, IgG4 and IgA antibodies were

associated with increased exposure, while the highest levels of exposure

were associated with a somewhat reduced level of mould-specific IgE antibodies "

_http://www.ingentaconnect.com/content/bsc/sji/2007/00000066/00000006/art00014

;jsessionid=vpp30g9wlfwi.henrietta_

(http://www.ingentaconnect.com/content/bsc/sji/2007/00000066/00000006/art00014;j\

sessionid=vpp30g9wlfwi.henrietta)

Abstract:

Exposure to moulds is thought to cause adverse health effects ranging from

vague subjective symptoms to allergy and respiratory diseases. Until now, most

studies have been emphasizing low levels of exposure. In Norwegian sawmills

during the 1980s, extensively high spore counts up to 107 spores/m3 air were

reported. By using serum samples obtained from sawmill workers during that

period, in addition to control sera, we studied the antibody response of all

classes and IgG subclasses to Rhizopus microsporus at different levels of

exposure. Antigen specificity was further studied by Western blotting. Exposure

to

R. microsporus was accompanied by R. microsporus-specific antibody

production against a wide range of antigenic components most likely of both

protein

and carbohydrate nature. Increasing levels of mould-specific IgG1, IgG2, IgG4

and IgA antibodies were associated with increased exposure, while the highest

levels of exposure were associated with a somewhat reduced level of

mould-specific IgE antibodies. In conclusion, the present study strongly

suggests that

high mould exposure can induce a strong IgG and IgA response in a

dose-dependent manner.

Document Type: Research article

DOI: 10.1111/j.1365-3083.2007.02022.x

************************************** See what's new at http://www.aol.com

[Guest guest]

Sharon, I just got a call from Marcie McGovern in Texas and her

doctor's nurse called with her IgG immune panel results. Her total

serum count is 349. Sub Class 1 is at 228, Sub Class 2 is 117

(borderline), Sub Class 3 is 22 (very low), Sub Class 4 is at 1

(extremely low). The nurse told Marcie to continue with the IgG

infusions, and Marcie's response to this was due to the allotment of

the IgG due to the Texas Medical Board, there is no spot for Marcie

because she was up to 78 grams. Marcie does not know what she would

be at with the infusions now. Her open workers comp case, Marcie can

not have any treatment because she only has medicare. This is from Marcie

>

>

> Great find, KC!

> " Increasing levels of mould-specific IgG1, IgG2, IgG4 and IgA

antibodies were

> associated with increased exposure, while the highest levels of

exposure

> were associated with a somewhat reduced level of mould-specific IgE

antibodies "

>

_http://www.ingentaconnect.com/content/bsc/sji/2007/00000066/00000006/art00014

> ;jsessionid=vpp30g9wlfwi.henrietta_

>

(http://www.ingentaconnect.com/content/bsc/sji/2007/00000066/00000006/art00014;j\

sessionid=vpp30g9wlfwi.henrietta)

> Abstract:

> Exposure to moulds is thought to cause adverse health effects

ranging from

> vague subjective symptoms to allergy and respiratory diseases. Until

now, most

> studies have been emphasizing low levels of exposure. In Norwegian

sawmills

> during the 1980s, extensively high spore counts up to 107 spores/m3

air were

> reported. By using serum samples obtained from sawmill workers

during that

> period, in addition to control sera, we studied the antibody

response of all

> classes and IgG subclasses to Rhizopus microsporus at different

levels of

> exposure. Antigen specificity was further studied by Western

blotting. Exposure to

> R. microsporus was accompanied by R. microsporus-specific antibody

> production against a wide range of antigenic components most likely

of both protein

> and carbohydrate nature. Increasing levels of mould-specific IgG1,

IgG2, IgG4

> and IgA antibodies were associated with increased exposure, while

the highest

> levels of exposure were associated with a somewhat reduced level of

> mould-specific IgE antibodies. In conclusion, the present study

strongly suggests that

> high mould exposure can induce a strong IgG and IgA response in a

> dose-dependent manner.

>

> Document Type: Research article

> DOI: 10.1111/j.1365-3083.2007.02022.x

>

>

>

>

> ************************************** See what's new at

http://www.aol.com

>

>

>

[Guest guest]

Darlene/Marcie,

This is frightening that our medical community, especially the TMB

would stoop so low forbidding a patient from getting medical

treatment, all in the name of money.

Marcie, you are a fighter and probably one of the most wonderful

people I have come across in all my years. This just shouldn't be

happening. All and all even with the severity of your illness you

still have a wonderful sense of humor. Something that I will always

admire and the strength you have shown over the years.

Our thoughts and prayers go out to you and many others on this board

and many that we are unaware of that are suffering from this same

condition.

We love you,

KC & Sharon

>

> Sharon, I just got a call from Marcie McGovern in Texas and her

> doctor's nurse called with her IgG immune panel results. Her total

> serum count is 349. Sub Class 1 is at 228, Sub Class 2 is 117

> (borderline), Sub Class 3 is 22 (very low), Sub Class 4 is at 1

> (extremely low). The nurse told Marcie to continue with the IgG

> infusions, and Marcie's response to this was due to the allotment of

> the IgG due to the Texas Medical Board, there is no spot for Marcie

> because she was up to 78 grams. Marcie does not know what she would

> be at with the infusions now. Her open workers comp case, Marcie can

> not have any treatment because she only has medicare. This is from

Marcie

>

[Guest guest]

Darlene, please tell Marcie that we are all thinking about her.

and yes, haveing only medicare with this illness is very hard,it's

just not right. we need good meducal help too. mold took our health

and our jobs put us on medicare. grrr~~

hey KC, thanks,good find.