Does *aspirin* potentiate trichothecene mycotoxin toxicity?

[Guest guest]

Can anyone get the full version of this paper?

" acetylsalicylic acid " is ASPRIN, I am pretty sure, right?

Gen Pharmacol. 1991;22(6):1087-91.

Beneficial effect of dexamethasone in decreasing the lethality of

acute T-2 toxicosis.

Fricke RF, J.

U.S. Army Medical Research, Institute of Infectious Diseases, Ft

Detrick, Frederick, MD 21701-5011.

1. Steroidal and non-steroidal anti-inflammatory agents were

evaluated for effectiveness for treatment of acute T-2 toxicosis in

mice. 2. Non-steroidal agents, indomethacin, phenylbutazone, and

acetylsalicylic acid, either were ineffective, or potentiated the

lethality of T-2 toxin. 3. Of the anti-inflammatory steroids tested,

dexamethasone was the most effective. 4. Dexamethasone was

administered before, at the same time as, or after injection of T-2

toxin. 5. As the time between toxin exposure and treatment was

increased, there was a corresponding increase in lethality. 6. In

conclusion, steroidal, but not non-steroidal, anti-inflammatory agents

were effective in decreasing T-2 toxin-induced lethality.

PMID: 1810806 [PubMed - indexed for MEDLINE]