Re: turmeric - a curry spice for mold illness?

[Guest guest]

Don't know anything about it's effects on mold illness

but Dr Cherry did a show on natural pain relievers

about 3 years and turmeric was one of them.

--- LiveSimply <quackadillian@...> wrote:

> Hello,

>

> Is anyone using turmeric (the main ingredient in

> curries, a common

> food in South Asia) to help fight mold illness?

> Turmeric and cucumin

> (one of its active ingredients) are the subject of a

> lot of research

> these days that may be relevant to mold illness on

> various levels.

>

> There are hundreds of hits, not just these..

>

> Free Radic Biol Med. 2007 Dec 4

>

>

> Curcumin treatment alleviates the effects of

> glutathione depletion

> in vitro and in vivo: Therapeutic implications for

> Parkinson's disease

> explained via in silico studies.

>

> Jagatha B, Mythri RB, Vali S, Bharath MM.

>

> Department of Neurochemistry, National Institute

> of Mental Health

> and Neurosciences, 2900, Hosur Road Bangalore

> 560029, Karnataka,

> India.

>

> Oxidative stress has been implicated in the

> degeneration of

> dopaminergic neurons in the substantia nigra (SN) of

> Parkinson's

> disease (PD) patients. An important biochemical

> feature of

> presymptomatic PD is a significant depletion of the

> thiol antioxidant

> glutathione (GSH) in these neurons resulting in

> oxidative stress,

> mitochondrial dysfunction, and ultimately cell

> death. We have earlier

> demonstrated that curcumin, a natural polyphenol

> obtained from

> turmeric, protects against peroxynitrite-mediated

> mitochondrial

> dysfunction both in vitro and in vivo. Here we

> report that treatment

> of dopaminergic neuronal cells and mice with

> curcumin restores

> depletion of GSH levels, protects against protein

> oxidation, and

> preserves mitochondrial complex I activity which

> normally is impaired

> due to GSH loss. Using systems biology and dynamic

> modeling we have

> explained the mechanism of curcumin action in a

> model of mitochondrial

> dysfunction linked to GSH metabolism that

> corroborates the major

> findings of our experimental work. These data

> suggest that curcumin

> has potential therapeutic values for

> neurodegenerative diseases

> involving GSH depletion-mediated oxidative stress.

>

> PMID: 18166164 [PubMed - as supplied by

> publisher]

>

> Food Chem Toxicol. 2007 Oct 30 [Epub ahead of

> print]

> Related Articles, Links

> Click here to read

> Protective capacities of certain spices against

> peroxynitrite-mediated biomolecular damage.

>

> Ho SC, Tsai TH, Tsai PJ, Lin CC.

>

> Department of Food Science, Yuanpei University,

> No. 306, Yuanpei

> Street, Hsinchu 300, Taiwan, ROC.

>

> Peroxynitrite, a potent cytotoxic agent, can

> damage a variety of

> biomolecules such as proteins, lipids, and DNA, and

> is considered as

> one of the major pathological causes of several

> diseases. Therefore,

> it would appear likely that interception of

> peroxynitrite by certain

> dietary compounds may represent one mechanism by

> which such foods may

> exert their beneficial action in vivo. A number of

> researchers have

> speculated that certain spices, rich in phenolics,

> may, conceivably,

> act as potential protectors against the actions of

> peroxynitrite.

> Eight culinary spices including cardamom, cinnamon,

> cloves, cumin,

> nutmeg, paprika, rosemary and turmeric were selected

> for study

> purposes. Further, the protective effects of

> methanol extracts of such

> spices against peroxynitrite-mediated damage to

> proteins, lipids and

> DNA were evaluated as determined by these extracts'

> ability to

> attenuate the formation of, respectively,

> nitrotyrosine in albumin,

> thiobarbiturate acid-reactive substances (TBARS) in

> liposome and

> strand breakages for plasmid DNA. All of the tested

> spices exerted

> some level of protective ability against

> peroxynitrite-mediated

> biomolecular damage. Amongst them, cloves deserve

> special attention

> due to their outstanding protective abilities

> against two of three

> forms of peroxynitrite-mediated biomolecular damage.

> Additionally, the

> phenolic content of certain spices appears to

> correlate well with such

> spices' protective effect against

> peroxynitrite-mediated tyrosine

> nitration and lipid peroxidation. Such an

> observation indicates that

> phenolics present in the spices contributed to such

> spice-elicited

> protection against peroxynitrite toxicity.

>

> PMID: 18063286 [PubMed - as supplied by

> publisher]

>

> Front Biosci. 2008 Jan 1;13:2191-202.

> Related Articles, Links

> Click here to read

> Cell cycle control as a basis for cancer

> chemoprevention through

> dietary agents.

>

> Meeran SM, Katiyar SK.

>

> Department of Dermatology, University of Alabama

> at Birmingham,

> Birmingham, AL 35294, USA.

>

> The development of cancer is associated with

> disorders in the

> regulation of the cell cycle. The purpose of this

> review is to briefly

> summarize the known sequence of events that regulate

> cell cycle

> progression with an emphasis on the checkpoints and

> the mechanisms

> cell employ to insure DNA stability in the face of

> genotoxic stress.

> Key transitions in the cell cycle are regulated by

> the activities of

> various protein kinase complexes composed of cyclin

> and

> cyclin-dependent kinases (CDK) molecules. The

> cyclins are CDK binding

> partners which are required for kinase activity and

> their protein

> levels are intimately linked to the cell cycle

> stage. CDK activity can

> be regulated by other mechanisms, such as

> phosphorylation events, that

> may contribute to deregulation of cell cycle and the

> development of

> cancer. While fruits and vegetables are recommended

> for prevention of

> cancer, their active ingredients and mechanisms of

> action are less

> well understood. Here, we briefly present evidence

> that dietary agents

> identified from fruits and vegetables can act to

> modulate the effects

> of deregulated cell cycle checkpoints, and that this

> may contribute to

> the prevention of cancer. The agents include

> apigenin (celery,

> parsley), curcumin (turmeric),

> (-)-epigallocatechin-3-gallate (green

> tea), resveratrol (red grape, peanuts and berries),

> genistein

> (soybean), and silymarin (milk thistle). The

> teachings of Hippocrates

> are still true " let food be thy medicine and

> medicine be thy food " .

>

> Publication Types:

>

> * Research Support, N.I.H., Extramural

> * Research Support, U.S. Gov't, Non-P.H.S.

> * Review

>

>

> PMID: 17981702 [PubMed - indexed for MEDLINE]

>

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