Re: Itching, Cholestryamine and Serotonin

[Guest guest]

Cholestasis is a well known side effect of mycotoxin poisoning.

On Jan 25, 2008 7:22 AM, Kim <indypets1965@...> wrote:

> Cholestatic liver disease is frequently associated with generalized

> pruritus. Pruritus can precede other signs and symptoms. It first

> appears in hands and feet and in areas of pressure and is worse at

> night. This itching can be very severe and is a serious clinical

> problem. Severe unrelieved itch in these patients can be an

> indication for liver transplantation.

>

> " Although bile salts are not directly responsible for pruritus,

> treatment with cholestyramine that binds bile salts is effective in

> reducing itch in cholestatic disease. In addition to bile salts,

> cholestyramine binds other substances in the intestine that may be

> the basis for its effectiveness, since it has also been used

> successfully in uremic patients and in polycythemia vera.

>

> Cholestryamine has also been shown to improve itching of cholestasis,

> suggesting that serotonin is involved in the itch (Table 89-2). It

> also play a key role in intestinal secretions and bowel motility.

> Serotonin is presumed to be modulated by sex drive. About 95% of

> serotonin in the body is in the gut...that only leaves 5% for the

> CNS. Some researchers suspect that SSRIs like paroxetine (Paxil)

> might help decrease constipation because of effects on serotonin.

>

> 1.http://wiserwiki.com/Pruritus

> 2.http://www.medscape.com/viewarticle/533713

> 3.http://www.naturaldatabase.com/(S

> (z0ildi45losoqdmkvsnxqov2))/ce/ceCourse.aspx?

> s=ND & cs= & st=0 & li=0 & pm=5 & pc=05-28

>

[Guest guest]

Live, oh geez! Catscan recently taken shows something going on in my

liver ducts that radiologist has suggested further imaging for, an MRI

and MRCP of area. I have symptoms of bile blockage, including some

lower back pain. Concerned because it is general area I had cancer in

2004. Cancer was small amount accidentally found in abdominal surgery

for a different reason so a little worried. That's one reason I wish I

could be taken CSM now. Have appt Monday with another doctor to talk

to him.

I have had itching for a long time, and wrist rashes and other things

that indicate possible liver trouble but just now had the catscan of

abdomine.

Anyway, if there is a problem, perhaps liver doctor will give me CSM.

Maybe late but better late than never. It could be infection in ducts

I've read, so don't know yet. Interesting information I can use.

I have alot of trouble sleeping too and blood tests taken show

extremely low levels of serotin and doctor said that's probably why.

Started 5-HTP a few days ago but he said it might take a while to have

an effect.

--- In , LiveSimply <quackadillian@...>

wrote:

>

> Cholestasis is a well known side effect of mycotoxin poisoning.

>