Ambient Particulate Pollutants in the Ultrafine Range Promote Early Atherosclero

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Circ Res. 2008 Jan 17 [Epub ahead of print] Links

Ambient Particulate Pollutants in the Ultrafine Range Promote Early

Atherosclerosis and Systemic Oxidative Stress.

Araujo JA, Barajas B, Kleinman M, Wang X, BJ, Gong KW, Navab

M, Harkema J, Sioutas C, Lusis AJ, Nel AE.

Department of Medicine, Geffen School of Medicine, and

Department of Civil and Environmental Engineering, University of

Southern California, Los Angeles; Department of Community and

Environmental Medicine, University of California, Irvine; and

Department of Pathobiology and Diagnostic Investigation, Michigan

State University, East Lansing.

" Air pollution is associated with significant adverse health effects,

including increased cardiovascular morbidity and mortality. Exposure

to particulate matter with an aerodynamic diameter of <2.5 microm

(PM2.5) increases ischemic cardiovascular events and promotes

atherosclerosis. Moreover, there is increasing evidence that the

smallest pollutant particles pose the greatest danger because of

their high content of organic chemicals and prooxidative potential. "

http://www.ncbi.nlm.nih.gov/pubmed/18202315?dopt=AbstractPlus