Biochemical Impedance ....... of Vitamin B12 in Chronic Toxigenic Mold Exposure

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Biochemical Impedance on Intracellular Functions of Vitamin B12 in

Chronic Toxigenic Mold Exposures by Anyanwu, Ebere C.; Kanu, Ijeoma .

Scientific World Journal, 2007.

Abstract

A majority of patients with neurological disorders with chronic

exposures to toxigenic molds and mycotoxins has vitamin B12

deficiency that is unrelated to dietary insufficiency. Vitamin B12 is

a source of coenzymes, and participates in intracellular recycling of

methionine, and in methionine synthase reactions. The biochemical

processes that lead to B12 depletion and deficiency are not fully

understood. This paper examines and assesses various most likely

biochemical reasons that could impede upon the normal intracellular

functions of vitamin B12 that lead to neurological manifestations. By

biochemical implications and derivations, it is most likely that

mycotoxins interrupt the structure and function of vitamin B12

through reactive interference with the normal One-Carbon metabolism

leading to the observed clinical neurological manifestations such as

nerve damage and, demyelination, degeneration of PNS leading to

paralysis, progressive peripheral neuropathy, and spinal

degeneration.