Fw: incresed gut permeability in Crohn's patients

[Guest guest]

----- Forwarded Message ----To: CAChitter Sent: Tue, January 3, 2012 8:49:15 PMSubject: incresed gut permeability in Crohn's patientshttp://www.annals.org/content/105/6/883.short We found that 17 normal volunteers absorbed 215 ± 29.6 mg (mean ± SE), whereas 11 patients with Crohn's disease absorbed 514 ±94.7 mg and their 32 healthy relatives absorbed 566 ±62.4 mg. The twofold increase in permeability of patients and their relatives (p <0.005 compared with controls) indicates that the intestinal defect in the ability to exclude larger sized molecules is not secondary to clinically recognized intestinal inflammation, but is a primary

defect that may be an etiologic factor in this disease.