PEG asselerate oro-caecal transit slow gastric emptying

[Guest guest]

I put this in the files section but is in PDF or something I cannot post link. It was found in MedlineSmall doses of the unabsorbable substance polyethylene glycol 3350

accelerate oro-caecal transit, but slow gastric emptying in healthy subjects.

Coremans G, Vos R, Margaritis V, Ghoos Y, Janssens J.

Department of Gastroenterology, University

Hospital Gasthuisberg, KULeuven, Herestraat 49, B-3000 Leuven, Belgium.

s.Coremans@...

BACKGROUND: Polyethylene glycol 3350 increases stool frequency and accelerates

colonic transit. Used as a laxative, it proved effective in patients with

normal and slow transit. Although free of severe side effects, it may cause

nausea and vomiting. The effect of this substance on upper gut transit has not

been studied. AIM: To investigate the effect of polyethylene glycol 3350 on

gastric emptying and oro-caecal transit in 12 healthy subjects. METHODS: In a

randomised controlled study, isosmotic polyethylene glycol 3350 electrolyte

balanced solution, in the maximal recommended dose or isosmotic electrolyte

solution, was administered after breakfast and lunch on separate days. Gastric

half-emptying time and oro-caecal transit time were measured using

[13C]-octanoate and lactose-[13C] ureide breath tests. RESULTS: Isosmotic

polyethylene glycol 3350 electrolyte solution, as compared to isosmotic

electrolyte solution, decreased oro-caecal transit time from 424+/-28 to

314+/-17 min (P = 0.001). Gastric half-emptying time was significantly

increased (84+/-6 min versus 127+/-14 min; P = 0.006). CONCLUSION: Polyethylene

glycol 3350 accelerate oro-caecal transit in healthy subjects, but also cause

an important delay in gastric emptying. The delay in gastric emptying may be of

clinical significance in patients who have associated gastroparesis.

Publication Types:

·

Clinical Trial

·

Randomized Controlled Trial

PMID: 15733521 [PubMed - indexed for MEDLINE]