Scientist crack Job's syndrome, immune disease

[Guest guest]

March 13, 2008

Scientist crack Job's syndrome, immune disease

Checkbiotech.org - Basel,Switzerland*

http://www.checkbiotech.org/orphan_News_treatmentandhealth.aspx?

infoId=2752

Immunologists have made a breakthrough in understanding a rare

immune disease called Job's syndrome — so called because its

symptoms include recurring outbreaks of abscesses similar to the

boils suffered by the eponymous Biblical character.

The new research shows that sufferers lack a specific type of white

blood cell, leaving them open to repeated attack by certain

bacterial and fungal pathogens.

Writing online in this week's Nature, a team led by Douek

describes how sufferers of Job's syndrome, more properly called

hyper-IgE syndrome (HIES), are unable to produce cells called TH17

helper cells. These immune cells produce a protein called

interleukin-17, and are crucial for protection against invading

pathogens.

The discovery ties in with the fact that sufferers are known to have

defects in a gene called stat3, which is involved in the

differentiation of TH17 cells, a common type of white blood cell,

into their various specific types.

The lack of this particular component of the immune system explains

why sufferers experience repeated infections by the same pathogens,

particularly fungal infection and Staphylococcus bacteria.

Contact:

Douek

National Institute of Health

Bethesda MD, USA

Tel: +1 301 594 8484

E-mail: ddouek@...

[Guest guest]

I suspect this is what I have! And really... it was all due to my

JOB. For the 20 years I was there, I suffered a Breast abcess, and

also abscesses on my Buttocks and inner thighs. When I went to seek

Medical help, I was insulted by being told I needed to wash better!

The abscesses would seem to come around my monthly cycle and last

about 2 weeks. It was once sugested I probably had a staph infection.

knowing now, I was exposed to Chaetomium Mold and who knows what

other Molds, and also being exposed to the Bio-Hazardous conditions,

just as soon as I became totally disabled and no longer able to walk,

let alone work, It wasn't until I was completely away from the filthy

conditions, that I completely cleared up! Tracking back to my known

exposure time for 3 weeks, I had a color change from yellow to green

excrement. (sorry I know thats gross), but thats what I had to deal

with. And rather than running to the Dr every month just to be

insulted, I learned to open up these painfull abscesses on my own. I

have not had 1 abscess since I left my workplace, and although I am

so very sick now, in some ways I've never felt better! No more sinus

pain, no more " allergy attacks " no more migraines.

--- In , " tigerpaw2c " <tigerpaw2c@...>

wrote:

>

> March 13, 2008

> Scientist crack Job's syndrome, immune disease

> Checkbiotech.org - Basel,Switzerland*

>

> http://www.checkbiotech.org/orphan_News_treatmentandhealth.aspx?

> infoId=2752

>

> Immunologists have made a breakthrough in understanding a rare

> immune disease called Job's syndrome — so called because its

> symptoms include recurring outbreaks of abscesses similar to the

> boils suffered by the eponymous Biblical character.

> The new research shows that sufferers lack a specific type of white

> blood cell, leaving them open to repeated attack by certain

> bacterial and fungal pathogens.

>

> Writing online in this week's Nature, a team led by Douek

> describes how sufferers of Job's syndrome, more properly called

> hyper-IgE syndrome (HIES), are unable to produce cells called TH17

> helper cells. These immune cells produce a protein called

> interleukin-17, and are crucial for protection against invading

> pathogens.

>

> The discovery ties in with the fact that sufferers are known to

have

> defects in a gene called stat3, which is involved in the

> differentiation of TH17 cells, a common type of white blood cell,

> into their various specific types.

>

> The lack of this particular component of the immune system explains

> why sufferers experience repeated infections by the same pathogens,

> particularly fungal infection and Staphylococcus bacteria.

>

> Contact:

> Douek

> National Institute of Health

> Bethesda MD, USA

> Tel: +1 301 594 8484

> E-mail: ddouek@...

>