World Health Organization, Mineral Oils, Cancer

[Guest guest]

MINERAL OILS:UNTREATED AND MILDLY-TREATED OILS(Group 1)HIGHLY-REFINED OILS (Group 3)For definition of Groups, see Preamble Evaluation. Supplement 7: (1987) (p. 252) Mineral oilCAS No.: 8002-05-9Chem. Abstr. Name: Petroleum A. Evidence for carcinogenicity to humans (sufficient for untreated and mildly-treated oils; inadequate for highly-refined oils)Exposure to mineral oils that have been used in a variety of occupations, including mulespinning, metal machining and jute processing, has been associated strongly and consistently with the occurrence of squamous-cell cancers of the skin, and especially of the

scrotum [ref: 1]. Production processes for these oils have changed over time, and with more recent manufacturing methods highly-refined products are produced that contain smaller amounts of contaminants, such as polycyclic aromatic hydrocarbons. Excess mortality or morbidity from gastrointestinal malignancies was seen in two out of three cohort studies of metal workers (stomach cancer in two studies, large-bowel cancer in one): however, the only significant excess was for the sum of stomach cancer plus large-bowel cancer in one study. Four cases of scrotal cancer were detected in one relatively small cohort study of metal industry workers [ref: 1]. Among 682 turners with five or more years of exposure to mineral oils, five cases of squamous-cell carcinoma of the skin (four of the scrotum) occurred, with 0.3

expected [ref: 2]. In a case-control study, a relative risk of 4.9 was reported for the association of scrotal cancer with potential exposure of metal workers to mineral oils. Neither the actual levels of exposure nor the classification of the mineral oil to which the machine workers were potentially exposed was available in the reports of the epidemiological studies [ref: 1]. In a case-control study, an excess of sinonasal cancers was seen in toolsetters, set-up men and toolmakers [ref: 1]. In a series of 344 cases of scrotal cancer from 1936 to 1976, 62% had held occupations in which exposure to mineral oils was likely to have occurred. The median latent period was 34 years [ref. 3]. An examination of the incidence of second primary cancers among men with scrotal cancer demonstrated excess of

respiratory, upper alimentary tract and skin cancers; when the occupations were grouped, the excess was largely confined to those with exposure to oil [ref: 1]. Excesses of bladder cancer have been reported in case-control studies in several countries among machinists and engineers, who were possibly exposed to cutting oils containing aromatic amines and additives [ref: 1]. With regard to printing pressmen, one of two cohort studies addressing lung cancer showed an excess and one of two proportionate mortality studies showed a small, statistically nonsignificant excess of lung cancer among newspaper pressmen but no excess among non-newspaper pressmen; the other study did not address lung cancer. One of three proportionate mortality studies on manual workers in the printing industry, not specifically addressing

printing pressmen, did not show an increased lung cancer risk, whereas the other two studies found a statistically significant excess. One of two proportionate mortality studies of printing pressmen indicated a statistically significant increase of deaths from rectal cancer, and the other showed a statistically nonsignificant increase of deaths from colon cancer; the cohort study considering colorectal cancers did not show an increased occurrence. One proportionate mortality study among newspaper and other commercial printing pressmen showed a statistically significant excess of mortality from cancers of the buccal cavity and pharynx, whereas no such excess was observed in a cohort study. One case-control study indicated a statistically significant excess of cancers of the buccal cavity and pharynx. The findings regarding other

malignancies were inconsistent; scrotal cancers were not mentioned. The type and amount of exposure were usually not described; exposure to both mineral oils and carbon blacks (see p. 142) would probably have been involved [ref: 1]. In mortality statistics from the UK and from Washington State, USA, excesses of lung and skin cancer have been registered for jobs entailing exposure to mineral oils [ref: 1]. B. Evidence for carcinogenicity to animals (sufficient for untreated and mildly-treated oils; inadequate for highly-refined oils)Vacuum-distillate fractions, acid-treated oils, mildly-treated solvent-refined oils, mildly-treated hydrotreated oils, solvent extracts (aromatic oils) and some cutting oils produced skin tumour after repeated skin applications to mice. Similar treatment with high-boiling

catalytically-cracked oils produced skin tumours in rabbits and rhesus monkeys. Some severely solvent-refined oils did not produce skin tumours in mice. Highly-refined food-grade mineral oils did not produce skin tumours when applied to the skin of mice, although after intraperitoneal injection they produced plasma-cell neoplasms and reticulum-cell sarcomas in certain strains of mice [ref: 1]. It was agreed that, in accordance with the previous evaluation, 'the significant latter finding is difficult to interpret' [ref: 1]. C. Other relevant dataAn increase in the frequency of chromosomal aberrations was observed in the peripheral blood lymphocytes of glass workers exposed to mineral oil mists. Urine from workers in a cold-rolling steel plant exposed to oil mists of solvent-refined oils was mutagenic

to Salmonella typhimurium in the present of an exogenous metabolic system [ref: 4]. Special test protocols may be necessary to evaluate mineral oils adequately in short-term tests. Vacuum distillates from oil refining were reported to be mutagenic to S. typhimurium in the presence of an exogenous metabolic system. Positive findings were obtained when the concentration of the exogenous metabolic system was five to ten fold that used generally. Acid-treated oils were not mutagenic to S. typhimurium in the presence of an exogenous metabolic system; solvent- refined oils were reported to be mutagenic in the presence of an exogenous metabolic system. Hydrotreated oil was reported to be mutagenic to S. typhimurium in the presence of an exogenous metabolic system, while white oils, highly-refined steel-hardening oil

and solvent-refined steelrolling oils were not. Unused crankcase oil was mutagenic to S. typhimurium in the presence of an exogenous metabolic system, while in other studies no mutagenic activity was found. Used crankcase oil from both gasoline and diesel engines was mutagenic to S. typhimurium both in the presence and absence of a metabolic system [ref: 4]. Two insulation oils from highly-refined mineral-base oils induced transformation of Syrian hamster embryo cells and enhanced transformation of mouse C3H 10T1/2 cells. Unused new, re-refined and used crankcase oils induced transformation in Syrian hamster embryo cells [ref: 4]. Overall evaluationUntreated and mildly-treated oils are carcinogenic to humans (Group 1).Highly-refined oils are not classifiable as to their carcinogenicity to humans ( ----- Forwarded Message ----To: miralax Sent: Fri, May 4, 2012 10:07:26 AMSubject: World Health Organization, Mineral Oils, Cancer

There are all grades of mineral oils, but I thought this was interesting on exposures...

http://monographs.iarc.fr/ENG/Monographs/suppl7/suppl7.pdf

Carol

[Guest guest]

I'm assuming the kind people drink are the highly refined, it does say insufficient evidence, but I wouldn't drink it.

MINERAL OILS:

UNTREATED AND MILDLY-TREATED OILS

(Group 1)

HIGHLY-REFINED OILS

(Group 3)

For definition of Groups, see Preamble Evaluation.

Supplement 7: (1987) (p. 252)

Mineral oil

CAS No.: 8002-05-9

Chem. Abstr. Name: Petroleum

A. Evidence for carcinogenicity to humans (sufficient for untreated and mildly-treated oils;

inadequate for highly-refined oils)

Exposure to mineral oils that have been used in a variety of occupations, including mulespinning,

metal machining and jute processing, has been associated strongly and consistently with the

occurrence of squamous-cell cancers of the skin, and especially of the scrotum [ref: 1]. Production

processes for these oils have changed over time, and with more recent manufacturing methods

highly-refined products are produced that contain smaller amounts of contaminants, such as

polycyclic aromatic hydrocarbons.

Excess mortality or morbidity from gastrointestinal malignancies was seen in two out of three cohort

studies of metal workers (stomach cancer in two studies, large-bowel cancer in one): however, the

only significant excess was for the sum of stomach cancer plus large-bowel cancer in one study.

Four cases of scrotal cancer were detected in one relatively small cohort study of metal industry

workers [ref: 1]. Among 682 turners with five or more years of exposure to mineral oils, five cases

of squamous-cell carcinoma of the skin (four of the scrotum) occurred, with 0.3 expected [ref: 2].

In a case-control study, a relative risk of 4.9 was reported for the association of scrotal cancer with

potential exposure of metal workers to mineral oils. Neither the actual levels of exposure nor the

classification of the mineral oil to which the machine workers were potentially exposed was available

in the reports of the epidemiological studies [ref: 1].

In a case-control study, an excess of sinonasal cancers was seen in toolsetters, set-up men and

toolmakers [ref: 1]. In a series of 344 cases of scrotal cancer from 1936 to 1976, 62% had held

occupations in which exposure to mineral oils was likely to have occurred. The median latent period

was 34 years [ref. 3].

An examination of the incidence of second primary cancers among men with scrotal cancer

demonstrated excess of respiratory, upper alimentary tract and skin cancers; when the occupations

were grouped, the excess was largely confined to those with exposure to oil [ref: 1].

Excesses of bladder cancer have been reported in case-control studies in several countries among

machinists and engineers, who were possibly exposed to cutting oils containing aromatic amines

and additives [ref: 1].

With regard to printing pressmen, one of two cohort studies addressing lung cancer showed an

excess and one of two proportionate mortality studies showed a small, statistically nonsignificant

excess of lung cancer among newspaper pressmen but no excess among non-newspaper pressmen;

the other study did not address lung cancer. One of three proportionate mortality studies on manual

workers in the printing industry, not specifically addressing printing pressmen, did not show an

increased lung cancer risk, whereas the other two studies found a statistically significant excess.

One of two proportionate mortality studies of printing pressmen indicated a statistically significant increase of deaths from rectal cancer, and the other showed a statistically nonsignificant increase of

deaths from colon cancer; the cohort study considering colorectal cancers did not show an increased

occurrence. One proportionate mortality study among newspaper and other commercial printing

pressmen showed a statistically significant excess of mortality from cancers of the buccal cavity and

pharynx, whereas no such excess was observed in a cohort study. One case-control study indicated

a statistically significant excess of cancers of the buccal cavity and pharynx. The findings regarding

other malignancies were inconsistent; scrotal cancers were not mentioned. The type and amount of

exposure were usually not described; exposure to both mineral oils and carbon blacks (see p. 142)

would probably have been involved [ref: 1].

In mortality statistics from the UK and from Washington State, USA, excesses of lung and skin

cancer have been registered for jobs entailing exposure to mineral oils [ref: 1].

B. Evidence for carcinogenicity to animals (sufficient for untreated and mildly-treated oils;

inadequate for highly-refined oils)

Vacuum-distillate fractions, acid-treated oils, mildly-treated solvent-refined oils, mildly-treated

hydrotreated oils, solvent extracts (aromatic oils) and some cutting oils produced skin tumour after

repeated skin applications to mice. Similar treatment with high-boiling catalytically-cracked oils

produced skin tumours in rabbits and rhesus monkeys. Some severely solvent-refined oils did not

produce skin tumours in mice. Highly-refined food-grade mineral oils did not produce skin tumours

when applied to the skin of mice, although after intraperitoneal injection they produced plasma-cell

neoplasms and reticulum-cell sarcomas in certain strains of mice [ref: 1]. It was agreed that, in

accordance with the previous evaluation, 'the significant latter finding is difficult to interpret' [ref:

1].

C. Other relevant data

An increase in the frequency of chromosomal aberrations was observed in the peripheral blood

lymphocytes of glass workers exposed to mineral oil mists. Urine from workers in a cold-rolling steel

plant exposed to oil mists of solvent-refined oils was mutagenic to Salmonella typhimurium in the

present of an exogenous metabolic system [ref: 4].

Special test protocols may be necessary to evaluate mineral oils adequately in short-term tests.

Vacuum distillates from oil refining were reported to be mutagenic to S. typhimurium in the

presence of an exogenous metabolic system. Positive findings were obtained when the concentration

of the exogenous metabolic system was five to ten fold that used generally. Acid-treated oils were

not mutagenic to S. typhimurium in the presence of an exogenous metabolic system; solvent-

refined oils were reported to be mutagenic in the presence of an exogenous metabolic system.

Hydrotreated oil was reported to be mutagenic to S. typhimurium in the presence of an exogenous

metabolic system, while white oils, highly-refined steel-hardening oil and solvent-refined steelrolling oils were not. Unused crankcase oil was mutagenic to S. typhimurium in the presence of an

exogenous metabolic system, while in other studies no mutagenic activity was found. Used

crankcase oil from both gasoline and diesel engines was mutagenic to S. typhimurium both in the

presence and absence of a metabolic system [ref: 4].

Two insulation oils from highly-refined mineral-base oils induced transformation of Syrian hamster

embryo cells and enhanced transformation of mouse C3H 10T1/2 cells. Unused new, re-refined and

used crankcase oils induced transformation in Syrian hamster embryo cells [ref: 4].

Overall evaluation

Untreated and mildly-treated oils are carcinogenic to humans (Group 1).

Highly-refined oils are not classifiable as to their carcinogenicity to humans (

----- Forwarded Message ----To: miralax Sent: Fri, May 4, 2012 10:07:26 AMSubject: World Health Organization, Mineral Oils, Cancer

There are all grades of mineral oils, but I thought this was interesting on exposures...

http://monographs.iarc.fr/ENG/Monographs/suppl7/suppl7.pdf

Carol