Lower urinary tract symptoms in dementia with Lewy bodies, Parkinson disease, an

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Lower urinary tract symptoms in dementia with Lewy bodies, Parkinson

disease, and Alzheimer disease

NEUROLOGY 2008;70:299-303

Objective: The present study sought to investigate lower urinary

tract symptoms and urodynamic and cystometric findings in Parkinson

disease (PD), dementia with Lewy bodies (DLB), and Alzheimer disease

(AD).

Methods: Included were patients with frequency, urgency,

incontinence, and nocturia, without major bladder outflow

obstruction. The protocol comprised physical examination, urine

analysis, prostate specific antigen, 24-hours frequency of

micturition, mean voided volume (MVV), free flow before

instrumentation (Qmaxbefore), post-void residual volume (PVR), and

cystometry.

Results: Fifteen patients with DLB and PD and 16 patients with AD

were examined. MVV, PVR, Qmaxbefore and with transurethral catheter,

cystometric bladder capacity, and detrusor pressor at maximum flow

were similar in the three groups and corresponded to values of the

general elderly population. Urge episodes and urge incontinence were

observed in 93 and 53% of the patients with DLB, 53 and 27% of the

patients with PD, and 19 and 12% of the patients with AD, and

detrusor overactivity in 92% of the patients with DLB, 46% of the

patients with PD, and 40% of the patients with AD.

Conclusions: Urgency and urge incontinence suggest detrusor

overactivity, which was more prevalent in dementia with Lewy bodies

than in Parkinson disease and Alzheimer disease, whereas mean voided

volume, free flow, cystometric bladder capacity, and detrusor pressor

were similar in the groups. Frequency of micturition could not be

reliably assessed in patients with dementia.

Source:

http://www.neurology.org/cgi/content/short/70/4/299?rss=1